Wound infections are one of the most common hospital acquired infections and are an important cause of morbidity and mortality. The objective of this study is to determine the causative aerobic bacteria and antimicrobial sensitivity of wound infections from pus specimen.The study population included patients admitted to different wards in the hospital and also those attending the out patient department. A total of 133 pus samples were received and were processed by doing Gram s stain and culture. Out of them 57% of the samples were obtained from surgical wound infections and 43 % of the samples were obtained from non-surgical wounds. Out of the 133 pus samples 66 samples (59.6%) were culture positive. Staphylococcus aureus was the most frequently isolated organism (30.88%) followed by Pseudomonas aeruginosa (25.02 %). Gram positive cocci were mostly sensitive to Amikacin (90.4%) followed by Levofloxaccin(76.1%).Among the Gram negative isolates Pseudomonas species were mostly sensitive to Amikacin (82.4%) followed by Ofloxacin (76.4%), Escherichia coli and Proteus species were 100% sensitive to Amikacin. Klebsiella species were sensitive to both Amikacin and Gentamicin (90.9%). A knowledge about the bacteriological profile and their antibiotic susceptibility pattern of wound infections will guide in appropriate treatment.