The tuberculin skin test (TST) done with purified protein derivative (PPD) by the Mantoux method, is useful for screening for TB infection in vivo .The objective of this study is to determine the frequency of Mantoux test positive in those infected with human immunodeficiency virus (HIV) and to investigate its association with CD4-T cell count, to know the percentage of people with HIV suffering with tuberculosis and at risk for tuberculosis. The study group consisted of 40 diagnosed HIV positive patients both newly diagnosed and old cases. Mantoux test was performed and the CD4 lymphocyte counts estimated by flow cytometry in 40 HIV-positive patients. Out of the 40 HIV patients 14 were Mantoux positive and 26 were Mantoux negative. Old HIV positive patients were mostly Mantoux positive though the CD4 cell counts in both groups were almost similar. Mantoux test positivity decreased with the decreasing CD4 cell counts. And it was found that the subjects with CD4 cell counts between 0-200 were mostly Mantoux negative. Mantoux test can be used as a diagnostic tool for decreasing immunity in HIV patients but to predict Tuberculosis in HIV patients more tests are required.