International Journal of Current Microbiology and Applied Sciences
ISSN: 2319-7706 Volume 2 Number 8 (2013) pp. 330-337
Antibiotic susceptibility pattern of Klebsiella pneumoniae isolated from urine samples
C.Manikandan* and A.Amsath
P.G. and Research Department of Zoology, Khadir Mohideen College, Adirampattinam-614701, Tamil Nadu, India *Corresponding author e-mail:
Urinary tract Infection (UTI) is among the most common infections described in outpatient setting and hospital patients. Klebsiella species isolated from urine samples from Gangasaras Diagnostic and Research Centre, Pattukkottai, Tamilnadu, were studied to determine the antimicrobial susceptibility pattern. Between January 2012 and December 2012, a total of 2400 specimens processed in the laboratory, of which 72 (11.2%) yielded Klebsiella species, from outpatients and inpatients. Organisms were identified by conventional methods. Klebsilla species were isolated mostly from female urine specimens. Antimicrobial susceptibility was done by the disk diffusion methods. The antimicrobial disk used include: amoxicillin, ampicillin, cefotaxime, ceftazidime, ceftriaxone, cephalexin, ciprofloxacin, nalidixic acid, norfloxacin, ofloxacin, amikacin, gentamicin, tobramycin, imipenem, nitrofurantoin, and cotrimoxazole. All were Himedia products. Antimicrobial susceptibility to various group drugs used was generally poor. The most sensitive antimicrobial was amikacin and imipenem with 62 (86.1%) isolates susceptible to it, followed by gentamicin and tobramycin with 58 (80.6%), ofloxacin with 57 (79.2%), ciprofloxacin with 55 (76.4%). 30 (41.7%) isolates were multiresistant to all the antimicrobial agents used. The result of this study will help in the empiric therapy of infection caused by Klebsiella species in Tamil Nadu State, but continuous surverillance of antimicrobial resistance of the organism is very necessary in the formulation of a sound antibiotic policy in the hospital.
Urine infection; Antimicrobial susceptibility; Resistant; Disk diffusion methods; antimicrobial resistance ;Klebsiella species.