International Journal of Current Microbiology and Applied Sciences
ISSN: 2319-7706 Volume 2 Number 8 (2013) pp. 286-295
Immunomodulatory activity of Phallusia nigra Savigny, 1816 against S-180
V.K.Meenakshi*, M. Paripooranaselvi, S. Sankaravadivoo, S. Gomathy and K.P. Chamundeeswari
Department of Zoology, A.P.C.Mahalaxmi College for Women, Tuticorin, Tamilnadu, India *Corresponding author e-mail:
Immunomodulatory activity of ethanolic extract of simple ascidian Phallusia nigra was determined against sarcoma 180 (S-180) cells. For 0.60 mg/ml concentration, 100% toxicity was observed. The extract administration at 50, 100 150 and standard drug Vincristin at 80 mg/kg body weight to different groups showed significant reduction in weight of body. The relative organ weight did not register any significant change. The results indicated that extract inhibited tumor growth by 52.69% compared to 47.12% in the standard drug treated group. The extract also significantly increased immune functions by increasing quantitative hemolysis of sheep RBC, lymphocyte proliferation, NK cytotoxicity and phagocytosis rate. The immunomodulatory effect was dose dependent. It is suggested that bioactive compounds present in Phallusia nigra modulates immune functions and hence may play a vital role in cancer prevention and treatment.
Phallusia nigra; immuno- modulatory; Cytotoxicity; antitumoral; S-180.