National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Acinetobacter causes a wide variety of illness in debilitated and hospitalized patients. Carbapenem resistance in Acinetobacter is an emerging problem and is a cause of concern as many nosocomial infections with Acinetobacter are resistant to most other antibiotics. The present study was aimed to study metallo-β-lactamase (MBL) production in Acinetobacter species. During one year study (Sep.2010 to Aug.2011), all isolates of Acinetobacter obtained from various clinical samples like respiratory, pus, blood and others were included. Antimicrobial susceptibility testing was done by standard Kirby Bauer disk diffusion method. Metallo β-lactamase (MBL) detection was done by imipenem-EDTA combined disk method. Among 200 isolates, 21 were Acinetobacter spp. Out of these 21, 8 were MBL producing Acinetobacter spp. The MBL producing strains were most frequently recovered from urine 37.5% (03/08) followed by sputum and respiratory tract specimens 25% (02/08), blood 25% (02/08) and pus and other wound discharges 12.5% (01/08) respectively. MBL producing Acinetobacter spp. were 100% sensitive to colistin and polimyxin B followed by amikacin (37.50%), ceftriaxone and ciprofloxacin (12.50%) respectively, but highly resistant to ceftazidime, doxycycline, nitrofurantoin, imepenem, meropenem and tobramycin. MBL positive isolates of Acinetobacter spp. showed higher resistance as compared to MBL negative isolates. This study demonstrated that multidrug resistant strains of Acinetobacter are common in tertiary care hospitals. Unwarranted and unrestricted usage of antibiotics is associated with emergence of resistance in nosocomial pathogens. Regular monitoring and documentation of carbapenem resistant is crucial in developing strategies to control infection due to these bacteria.
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