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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 2521-2526
DOI: https://doi.org/10.20546/ijcmas.2018.709.313


Study of Prevalence and Antimicrobial Susceptibility Pattern of Matello-Beta-Lactamase Producing Acinetobacter spp. Isolated at a Tertiary Care Institute in North West Region of Rajasthan
Abhishek Binnani, B.R. Bishnoi, Saroj Meena* and Dhara Singh
Department of Microbiology, Sardar Patel Medical College, Bikaner, Rajasthan, India
*Corresponding author
Abstract:

Acinetobacter causes a wide variety of illness in debilitated and hospitalized patients. Carbapenem resistance in Acinetobacter is an emerging problem and is a cause of concern as many nosocomial infections with Acinetobacter are resistant to most other antibiotics. The present study was aimed to study metallo-β-lactamase (MBL) production in Acinetobacter species. During one year study (Sep.2010 to Aug.2011), all isolates of Acinetobacter obtained from various clinical samples like respiratory, pus, blood and others were included. Antimicrobial susceptibility testing was done by standard Kirby Bauer disk diffusion method. Metallo β-lactamase (MBL) detection was done by imipenem-EDTA combined disk method. Among 200 isolates, 21 were Acinetobacter spp. Out of these 21, 8 were MBL producing Acinetobacter spp. The MBL producing strains were most frequently recovered from urine 37.5% (03/08) followed by sputum and respiratory tract specimens 25% (02/08), blood 25% (02/08) and pus and other wound discharges 12.5% (01/08) respectively. MBL producing Acinetobacter spp. were 100% sensitive to colistin and polimyxin B followed by amikacin (37.50%), ceftriaxone and ciprofloxacin (12.50%) respectively, but highly resistant to ceftazidime, doxycycline, nitrofurantoin, imepenem, meropenem and tobramycin. MBL positive isolates of Acinetobacter spp. showed higher resistance as compared to MBL negative isolates. This study demonstrated that multidrug resistant strains of Acinetobacter are common in tertiary care hospitals. Unwarranted and unrestricted usage of antibiotics is associated with emergence of resistance in nosocomial pathogens. Regular monitoring and documentation of carbapenem resistant is crucial in developing strategies to control infection due to these bacteria.


Keywords: Carbapenem resistance, Metallo ß-lactamase, A. baumannii
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How to cite this article:

Abhishek Binnani, B.R. Bishnoi, Saroj Meena and Dhara Singh. 2018. Study of Prevalence and Antimicrobial Susceptibility Pattern of Matello-Beta-Lactamase Producing Acinetobacter spp. Isolated at a Tertiary Care Institute in North West Region of Rajasthan.Int.J.Curr.Microbiol.App.Sci. 7(9): 2521-2526. doi: https://doi.org/10.20546/ijcmas.2018.709.313