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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 1612-1621
DOI: https://doi.org/10.20546/ijcmas.2018.709.193


The Bacteriological and Antimicrobial Susceptibility Profile of Cerebrospinal Fluid Isolates in a Tertiary Hospital, Northeast India
Mandira Ramudamu and Annie B. Khyriem*
Department of Microbiology, Neigrihms, Shillong, Meghalaya, India
*Corresponding author
Abstract:

CNS infections are life-threatening and significant causes of morbidity and mortality, especially in developing countries. To ensure appropriate therapy, current knowledge of the organisms that cause CNS infection and their antibiotic susceptibility pattern in a particular setting or region is of utmost importance. This study was therefore undertaken to determine bacterial isolates and their antibiogram in the cerebrospinal fluids of patients as seen at Tertiary Hospital. The study was carried out at a tertiary care hospital from June 2016 to December 2016 irrespective of age group. Cerebrospinal fluid (CSF) samples were subjected for bacteriological analysis. Total samples received were 639 out of which 57 samples showed growth. Only 40 pathogens were isolated in culture, which amounts to isolation rate of 7.67%. Gram negative isolation rate (70%) was more than gram positive organism (30%) but the most common organism that was isolated was Enterococcus spp. Most common Gram negative isolate was Acinetobacter baumanii (11.8%), followed by Escherichia coli (10.17%). Gram negative organisms showed higher resistance to beta lactam antibiotics like piperacillin (61.54%), ampicillin (80%). cephalosporins like cefotaxime (81.25%), cefoperazone (63.64%) and ceftriaxone (50%) resistance rates were also on the higher side. Cotrimoxazole resistance was also bit high 57.89%. Out of 9 Enterococcus species we isolated, 5 were HLAR (High level Aminoglycoside resistant). Though HLAR Enterococcus species showed 100% resistance to Penicillin, Ampicillin, Ciprofloxacin but were susceptible to drugs like Vancomycin, Linezolid and Teicoplanin. CNS infections are life-threatening and significant causes of morbidity and mortality, so early management is essential. Since we are encountering resistance to commonly used antibiotics, so microbiological surveillance is important to identify the common pathogens and their antimicrobial susceptibility patterns in order to select the rational empirical antimicrobial therapy based on regional and national data to reduce the emergence of resistant organisms


Keywords: Bacteriological Profile, Antibiogram, CSF
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How to cite this article:

Mandira Ramudamu and Annie B. Khyriem. 2018. The Bacteriological and Antimicrobial Susceptibility Profile of Cerebrospinal Fluid Isolates in a Tertiary Hospital, Northeast India.Int.J.Curr.Microbiol.App.Sci. 7(9): 1612-1621. doi: https://doi.org/10.20546/ijcmas.2018.709.193