National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
CNS infections are life-threatening and significant causes of morbidity and mortality, especially in developing countries. To ensure appropriate therapy, current knowledge of the organisms that cause CNS infection and their antibiotic susceptibility pattern in a particular setting or region is of utmost importance. This study was therefore undertaken to determine bacterial isolates and their antibiogram in the cerebrospinal fluids of patients as seen at Tertiary Hospital. The study was carried out at a tertiary care hospital from June 2016 to December 2016 irrespective of age group. Cerebrospinal fluid (CSF) samples were subjected for bacteriological analysis. Total samples received were 639 out of which 57 samples showed growth. Only 40 pathogens were isolated in culture, which amounts to isolation rate of 7.67%. Gram negative isolation rate (70%) was more than gram positive organism (30%) but the most common organism that was isolated was Enterococcus spp. Most common Gram negative isolate was Acinetobacter baumanii (11.8%), followed by Escherichia coli (10.17%). Gram negative organisms showed higher resistance to beta lactam antibiotics like piperacillin (61.54%), ampicillin (80%). cephalosporins like cefotaxime (81.25%), cefoperazone (63.64%) and ceftriaxone (50%) resistance rates were also on the higher side. Cotrimoxazole resistance was also bit high 57.89%. Out of 9 Enterococcus species we isolated, 5 were HLAR (High level Aminoglycoside resistant). Though HLAR Enterococcus species showed 100% resistance to Penicillin, Ampicillin, Ciprofloxacin but were susceptible to drugs like Vancomycin, Linezolid and Teicoplanin. CNS infections are life-threatening and significant causes of morbidity and mortality, so early management is essential. Since we are encountering resistance to commonly used antibiotics, so microbiological surveillance is important to identify the common pathogens and their antimicrobial susceptibility patterns in order to select the rational empirical antimicrobial therapy based on regional and national data to reduce the emergence of resistant organisms
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