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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(9): 1061-1069
DOI: https://doi.org/10.20546/ijcmas.2018.709.126


Prevalence and Antibiotic Resistant Pattern of Pseudomonas aeruginosa at a Tertiary Care Centre of North India
Trinain Kumar Chakraverti1 and Purti C. Tripathi2*
1Department of Microbiology, Patna Medical College, Patna – 800004, India
2Department of Microbiology, Government Medical College, Chhindwara, Madhya Pradesh – 480001, India
*Corresponding author
Abstract:

The aim of this study was to analyze the extended spectrum of β lactamase (ESBL), metallo β lactamase (MBL) and AmpC production in Pseudomonas aeruginosa in various clinical samples. A Total of 100 clinical isolates of P. aeruginosa were collected from different clinical specimen and confirmed by standard tests. Antibiotic susceptibility was determined by the Kirby-Bauer disc diffusion method. ESBL screening was done using 3rd generation cephalosporins and confirmatory combined double disc test, imipenem-EDTA double disc synergy test for MBL enzyme and AmpC test using Cefoxitin disc. Out of 100 clinical P.aeruginosa isolates, 33% were ESBL producer, 18 % MBL producer both ESB and MBL 9% and none were AmpC producer. Imipenem (81%), meropenem (82%), aminoglycosides (amikacin (72%), tobramycin (74%), netilmycin (71%) and Polymyxin B(100%) and colistin (100%) has got the better antipseudomonal activity. 28 (28%) P.aeruginosa was found to be Multi Drug Resistant (MDR). This study highlights the prevalence of ESBL, MBL and MDR P.aeruginosa. In our study Carbapenems and aminoglycosides are promising drugs with antipseudomonal activity while polymyxin b and colstin use as reserved drug.


Keywords: Pseudomonas aeruginosa, Multi-drug resistance, Extended spectrum of β lactamase (ESBL), Metallo β lactamase (MBL)
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How to cite this article:

Trinain Kumar Chakraverti and Purti C. Tripathi. 2018. Prevalence and Antibiotic Resistant Pattern of Pseudomonas aeruginosa at a Tertiary Care Centre of North India.Int.J.Curr.Microbiol.App.Sci. 7(9): 1061-1069. doi: https://doi.org/10.20546/ijcmas.2018.709.126