National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in the first four weeks of life. Neonatal septicaemia remains one of the most important causes of mortality despite considerable progress in hygiene, introduction of new antimicrobial agents and advanced measures for early diagnosis and treatment. In this cross-sectional study, blood samples from the suspected infants were collected and processed in the bacteriology laboratory. The growth was identified by standard microbiological protocol and the antibiotic sensitivity testing was carried out on MHA by Kirby-Bauer disk diffusion method as recommended in CLSI guidelines. Out of the 147 neonates (M: F = 1.3: 1) admitted to the NICU, 52 (35.4%) shows blood culture positive. Gram positive was the major organism isolated 46 (88.5%), followed by Gram negative organism 6 (11.5%). CoNS (63%) was the predominant Gram positive organism and Klebsiella species (66.6%) was the predominant Gram negative organism. Best overall sensitivity among Gram positive isolates was to vancomycin (100%) and linezolid (100%). High level resistance was seen against penicillin and fluoroquinolones. Gram negative isolates demonstrated highest sensitivity against imipenem (100%) and ciprofloxacin (100%). High level resistance was seen against cephalosporins. Neonatal septicaemia is associated with the significant mortality and morbidity. Due to changing micrbiological and antibiotic pattern, a regular surveillance is necessary and blood culture is the gold standard method for diagnosis and should be done in all the suspected cases of neonatal sepsis.
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