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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(8): 3999-4005
DOI: https://doi.org/10.20546/ijcmas.2018.708.414


Bacteriological Profile and Antibiogram of Neonatal Septicemia in a Tertiary Care Hospital
Bipin Gupta1, Sneha Mohan1, Anjali Agarwal2 and Renu Dutta1
1Department of Microbiology, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India
2Department of Microbiology, Hind Institute of Medical Sciences, Barabanki, Uttar Pradesh, India
*Corresponding author
Abstract:

Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in the first four weeks of life. Neonatal septicaemia remains one of the most important causes of mortality despite considerable progress in hygiene, introduction of new antimicrobial agents and advanced measures for early diagnosis and treatment. In this cross-sectional study, blood samples from the suspected infants were collected and processed in the bacteriology laboratory. The growth was identified by standard microbiological protocol and the antibiotic sensitivity testing was carried out on MHA by Kirby-Bauer disk diffusion method as recommended in CLSI guidelines. Out of the 147 neonates (M: F = 1.3: 1) admitted to the NICU, 52 (35.4%) shows blood culture positive. Gram positive was the major organism isolated 46 (88.5%), followed by Gram negative organism 6 (11.5%). CoNS (63%) was the predominant Gram positive organism and Klebsiella species (66.6%) was the predominant Gram negative organism. Best overall sensitivity among Gram positive isolates was to vancomycin (100%) and linezolid (100%). High level resistance was seen against penicillin and fluoroquinolones. Gram negative isolates demonstrated highest sensitivity against imipenem (100%) and ciprofloxacin (100%). High level resistance was seen against cephalosporins. Neonatal septicaemia is associated with the significant mortality and morbidity. Due to changing micrbiological and antibiotic pattern, a regular surveillance is necessary and blood culture is the gold standard method for diagnosis and should be done in all the suspected cases of neonatal sepsis.


Keywords: Neonatal sepsis, Blood culture, Antibiogram, CoNS, Klebsiella
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How to cite this article:

Bipin Gupta, Sneha Mohan, Anjali Agarwal and Renu Dutta. 2018. Bacteriological Profile and Antibiogram of Neonatal Septicemia in a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 7(8): 3999-4005. doi: https://doi.org/10.20546/ijcmas.2018.708.414