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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(8): 1820-1834
DOI: https://doi.org/10.20546/ijcmas.2018.708.209


Candidate Gene Polymorphism vis-a-vis Immune Response to Important Infectious Diseases in Bovines
Sushil Kumar*, Ran Vir Singh, Anuj Chauhan, Arvind Sonwane and Subodh Kumar
Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
*Corresponding author
Abstract:

Infectious diseases have major adverse effects on livestock production, both in terms of economics and on animal welfare. 10-25 % loss in milk production efficiency has been reported in tuberculosis infected animals. Udder infections alone account for annual economic loss of Rs. 6053.21 crores incurred by dairy industry in India. Similarly 10-25 % loss in milk production efficiency has been reported in tuberculosis infected animals. While traditional control measures such as vaccination, treatment and eradication exist, improving the genetic resistance to diseases among livestock populations is an effective alternate strategy as genetic gain is cumulative and permanent. Estimates of the heritability for susceptibility to Bovine Tuberculosis (BTB), MAP infection, Somatic Cell Count (SCC) were 0.18, 0.16 and 0.11 respectively demonstrating genetic variation for susceptibility to various infections in dairy cattle. In livestock, a number of candidate genes coding for proteins with very specific and unique roles in immune responses are potential strong candidates for investigating genetic basis of disease resistance have been investigated on the basis of their association to resistance or susceptibility in certain other diseases and their known role in disease pathogenesis. The advancement in marker research has potential implications in future selection programs if integrated with the complete genetic variant details and production traits of the herd.


Keywords: Candidate gene, Genetic marker, Resistance, Disease, Cattle.
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How to cite this article:

Sushil Kumar, Ran Vir Singh, Anuj Chauhan, Arvind Sonwane and Subodh Kumar. 2018. Candidate Gene Polymorphism vis-a-vis Immune Response to Important Infectious Diseases in Bovines.Int.J.Curr.Microbiol.App.Sci. 7(8): 1820-1834. doi: https://doi.org/10.20546/ijcmas.2018.708.209