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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(9): 725-732
DOI: http://dx.doi.org/10.20546/ijcmas.2016.509.083


Clinical Profile and Diagnostic Parameters of Dengue Viral Infection among Children
Asmabegaum M. Biradar1*, Shobha D. Nadagir2, Mahesh Kumar Shankar3 and Trupti B. Naik4
1Al- Ameen Medical College, Athani road, Vijayapur, 586109 Karnataka, India
2Navodaya Medical College, Raichur, Karnataka, India
3Karnataka institute of Medical Sciences, Hubballi, Karnataka, India
4Subbaiah Institute of Medical Sciences, Shivamogga., Karnataka, India  
*Corresponding author
Abstract:

Dengue fever is an acute febrile arbovirus disease. Dengue is almost endemic all over India. Complications caused are dengue hemorrhagic fever (DHF) and dengue shock syndrome(DSS).Present study was conducted to know the sero prevalence of dengue infection and correlate clinical manifestations and diagnostic parameters of dengue infection in children. We conducted a cross sectional study on patients with acute febrile illness, clinically diagnosed as having dengue fever as per the WHO criteria. Serum samples collected from these patients were tested for Detection of IgM antibody by MAC ELISA and immune chromatographic (IC) test. Detection of NS1 antigen by IC test. Detection of platelet count by automated machine. Among 200 dengue suspected cases 37(18.5%) were positive by IgM MAC ELISA, 22(11%) by IgM IC test and 12(6%) by NS1 antigen IC test, of which 7(3.5%) were positive by both IgM antibody and NS1antigen. Among seropositive, 35 (83.33%) revealed thrombocytopenia. Maximum children 27 (64.28%) presented with bleeding manifestation. However, no significant difference observed with hematocrit values. Prevalence of dengue infection was 21%. Most of them (59.53%) presented with DHF.  Significant association of thrombocytopenia found in dengue positive subjects, more so when NSI antigen and Ig M antibody are detected simultaneously.


Keywords: Dengue,IgM antibody, NS1, platelet count,IC test.
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How to cite this article:

Asmabegaum M. Biradar, Shobha D. Nadagir, Mahesh Kumar Shankar and Trupti B. NaiK. 2016. Clinical Profile and Diagnostic Parameters of Dengue Viral Infection among Children.Int.J.Curr.Microbiol.App.Sci. 5(9): 725-732. doi: http://dx.doi.org/10.20546/ijcmas.2016.509.083