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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(9): 718-724
DOI: http://dx.doi.org/10.20546/ijcmas.2016.509.082


Sclerostin and IL-1Ra in Rheumatoid Iraqi Patients after Biological Therapy
Sanan Th. Abdalwahab1*, Haider Sabah Kadhim2,Alauldeen Mudhafar Zubair Alqasim3 and Faiq I. Gorial4
1College of Medicine, Al-Mustansiriya University, Baghdad, Iraq
2College of Medicine, Al-Nahrain University, Baghdad, Iraq
3Department of Pathology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq
4Consultant Rheumatologist, Department of Medicine, College of Medicine, Baghdad University, Baghdad, Iraq  
*Corresponding author
Abstract:

Wnt pathway important in control of the bone formation through the regulation of osteoblast activity, and sclerostin is an important in the regulator of the Wnt pathway by blocking Wnt binding to its receptor and thereby inhibiting bone formation. Blockage of Wnt antagonists such as sclerostin will trigger repair or even healing of bone erosion. Recently show that IL-1Ra has been given important role in therapeutic and pathogenesis of Rheumatoid arthritis (RA). This study planned to evaluate the level of serum sclerostin and level of serum IL-1Ra, in addition to correlate the level of serum sclerostin and IL-1Ra with disease activity by (CDAI or DAS28) in thirty RA Iraqi patients treated with biological therapy (Etanercept). The results show that sclerostin level within normal range in healthy and patients but higher in healthy than patients with biological treatment, also IL-1Ra within normal range in healthy and patients but higher in healthy than patients with biological treatment significant difference (p<0.05).


Keywords: Rheumatoid arthritis,sclerostin,IL-1Ra, pathogenesis and etanercept.
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How to cite this article:

Sanan Th. Abdalwahab, Haider Sabah Kadhim, Alauldeen Mudhafar Zubair Alqasim and Faiq I. Gorial. 2016. Sclerostin and IL-1Ra in Rheumatoid Iraqi Patients after Biological Therapy.Int.J.Curr.Microbiol.App.Sci. 5(9): 718-724. doi: http://dx.doi.org/10.20546/ijcmas.2016.509.082