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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(8): 490-498
DOI: https://doi.org/10.20546/ijcmas.2018.708.054


Role of Procalcitonin in Diagnosis of Early Onset Neonatal Sepsis in a North Indian Tertiary Care Centre
Yogeeta Bala1, V.S. Randhawa1, Ravinder Kaur1, Arvind Saili2 and Shweta Chitkara1*
1Department of Microbiology
2Department of Neonatology, Lady Hardinge Medical College and associated hospitals, New Delhi-110001, India
*Corresponding author
Abstract:

Neonatal sepsis is a major cause of mortality in developing countries. Accurate and quick diagnosis is difficult because of non-specific signs and symptoms, cultures being time-consuming and other laboratory tests lack sensitivity and specificity. This study was designed to determine the sensitivity and specificity of Procalcitonin (PCT) levels, as a diagnostic marker of early onset neonatal sepsis (EONS). 150 neonates admitted to neonatal ward with signs suggestive of neonatal sepsis were recruited into the study. Prior to commencement of antibiotics, the following investigations were carried out on neonates: blood culture, PCT and C-reactive protein (CRP) estimation. The PCT levels were measured by human procalcitonin ELISA kit. The neonates were categorized into proven, probable and clinical sepsis on the basis of laboratory findings. Predictive values and area under the ROC curve of PCT were evaluated. Out of 150 neonates, 44 had positive blood cultures. PCT level was significantly higher in neonates with proven sepsis (p <0.05). At a cut-off of 1.32ng/ml, the sensitivity and specificity, PPV and NPV of PCT in early onset neonatal sepsis was found to be 86.3 %, 44.34 %, 39.58 % and 88.68 % respectively for proven sepsis. These findings support usefulness of the PCT in diagnosis of EONS.


Keywords: ELISA, Neonatal sepsis, Procalcitonin, ROC curve, Sensitivity, Specificity
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How to cite this article:

Yogeeta Bala, V.S. Randhawa, Ravinder Kaur, Arvind Saili and Shweta Chitkara. 2018. Role of Procalcitonin in Diagnosis of Early Onset Neonatal Sepsis in a North Indian Tertiary Care Centre.Int.J.Curr.Microbiol.App.Sci. 7(8): 490-498. doi: https://doi.org/10.20546/ijcmas.2018.708.054