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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here
ICV 2022: 95.28
Index Copernicus ICI Journals Master List 2022 - IJCMAS--ICV 2022: 95.28
For more details click here
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Original Research Articles                      Volume : 7, Issue:8, August, 2018
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com /
submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38
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Int.J.Curr.Microbiol.App.Sci.2018.7(8): 291-307
DOI: https://doi.org/10.20546/ijcmas.2018.708.034


Antidiabetic and Antilipidemic Effect of Khaya senegalensis Ethanolic Bark Extract in Alloxan Induced Diabetic Wistar Rats
R.U. Ukpanukpong1*, J.O. Ajani2, W.A. Omang1, M.A. Adejorin2, M.U. Eteng1 and E.U. Eyong1
1Department of Biochemistry, University of Calabar, Calabar-Nigeria
2Department of Chemical Sciences, Biochemistry Unit, Joseph Ayo Babalola University, Ikeji- Arakeji, Nigeria
*Corresponding author
Abstract:

This study investigated the anti-diabetic effect of ethanolic bark extract of Khaya senegalensis in Alloxan-induced diabetic albino Wistar rats. Sixty (60) female albino rats were randomly placed into six (6) study groups of ten (10) animals designated as; non-diabetic control (NDC), diabetic control (DC), and diabetic extract treated groups (DSB1, DSB2, and DSB3) receiving varying extract concentration of 100mg/kg, 200mg/kg, and 400mg/kg body weight respectively. Animals were sacrificed after 28 days of treatment and blood was obtained for biochemical analysis. Body weight indices obtained from this study revealed a decrease (p<0.05) in body weight in the extract treated group when compared with non-diabetic control with an attendant increase (p<0.05) when compared with diabetic control. Phytochemical screening detected biologically important metabolites including phenolics and steroids while haematological parameters such as packed cell volume and haemoglobin decreased in the extract treated group when compared with the non-diabetic control but significantly increased (p<0.05) when compared with diabetic control. Lipid profile showed a significant decrease (p<0.05) in total cholesterol and low density lipoprotein (LDL) in the extract treated group with an attendant increase when compared to the diabetic control and non-diabetic control respectively. Serum liver enzymes; alkaline phosphatase (ALP) and alanine transaminase (ALT) were increased in the extract treated group when compared to the non-diabetic control but a significant decrease (p<0.05) was observed in comparison with the diabetic control. In conclusion, data generated from this study show that ethanolic bark extract of Khaya senegalensis possesses antihyperglycaemic activities in alloxan induced diabetic rats.


Keywords: Phytochemicals, Glucose level Heamatological indices, Lipid Profile, Hepatic Serum Enzymes

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How to cite this article:

Ukpanukpong, R.U., J.O. Ajani, W.A. Omang, R.I. Oplekwu, M.A. Adejorin, M.U. Eteng and Eyong, E.U. 2018. Antidiabetic and Antilipidemic Effect of Khaya senegalensis Ethanolic Bark Extract in Alloxan Induced Diabetic Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 7(8): 291-307. doi: https://doi.org/10.20546/ijcmas.2018.708.034
Copyright: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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