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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(8): 280-290
DOI: https://doi.org/10.20546/ijcmas.2018.708.033


Assessment of Selected Hepatic Serum Enzymes in Contaminated Crude-Oil Feeds on Albino Wistar Rats
R.U. Ukpanukpong1*, D.I. Basiru1, O.O. Obadare2 and W.A. Omang1
1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Nigeria
2Department of Biochemistry, College of Natural Sciences, Joseph Ayo Babalola University, Ikeji -Arakeji Osun State, Nigeria
*Corresponding author
Abstract:

This study was aimed at investigating the effect of crude oil contaminated feeds on selected serum enzymes and electrolyte levels in Albino wistar rats. Albino wistar rats weighing between 180g to 200g were obtained from Ladoke Akintola University of Technology Ogbomosho, OyoState and used for the study. The animals were grouped into five study groups with six (6) animals in each group. The animals were kept in a well-ventilated room comprising control group, crude oil group, garlic treated group, Vitamin C treated group and Vitamin E treated group. The animals were fed with contaminated feeds 25mg of the antioxidant specified for each group simultaneously for two weeks. However, control group were only fed with the normal while the crude oil group was not treated with the antioxidant. The levels of LDH and GGT concentrations increased significantly (P>0.05) in crude oil only fed group but LDH showed low concentration on treatment with vitamin E(P<0.05).Garlic and vitamin C therefore do not have ameliorative effect on increased LDH and GGT levels of crude oil contamination. Vitamin E therefore reduced the toxic effect of the crude oil contamination on LDH significantly after 28 days. There was a significant increased (P>0.05) in the activities of AST, ALT, ALP in groups fed with crude oil contaminated diet when compared to the control and these sharp changes were ameliorated after 28 days of antioxidant treated groups.


Keywords: Body weight, Serum enzymes, Electrolyte level
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How to cite this article:

Ukpanukpong, R.U., D.I. Basiru, O.O. Obadare and Omang, W.A. 2018. Assessment of Selected Hepatic Serum Enzymes in Contaminated Crude-Oil Feeds on Albino Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 7(8): 280-290. doi: https://doi.org/10.20546/ijcmas.2018.708.033