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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(5): 3274-3283
DOI: https://doi.org/10.20546/ijcmas.2018.705.383


Curcumin May Enhance the Efficacy of Anti-Leukemia Drugs in Myeloid Leukemia
Apurba Mukherjee1, Kalyan Kusum Mukherjee2, Sutapa Mukherjee1 and Madhumita Roy1*
1Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata - 700 026, India
2Medical Oncology Department, Chittaranjan National Cancer Institute, 37, S P Mukherjee Road, Kolkata - 700 026, India
*Corresponding author
Abstract:

Myeloid leukemia may be classified as Acute Myeloid Leukemia (AML) or Chronic Myeloid Leukemia (CML) based on its rate of progression. Administration of drugs is the best modality to treat myeloid leukemia, Imatinib mesylate (IM) and cytarabine (cyt) for CML and AML respectively. However, these drugs show severe adverse effects on patients, thereby limiting their therapeutic efficacy. Hence, a safer intervention needs attention. Phytochemicals possess disease fighting properties and hence may be a solution to the problem. Curcumin, a common Indian spice is known to have anti-cancer properties. Present study aims to elucidate the role of curcumin as a chemo-enhancer in myeloid leukemia (CML and AML). Lymphocytes from freshly diagnosed patients (before administration of medication) have been used in this study. Certain proteins contributing to leukemogenesis are being targeted by IM and cyt. Curcumin efficiently modulates these target proteins and maximum effect is seen when drugs are used in conjunction with curcumin, where enhanced induction of apoptosis is facilitated. Curcumin therefore, improved the efficiency of conventional drugs used in myeloid leukemia therapy. This study suggests that curcumin may be used as a combinatorial therapy in leukemia in addition to existing treatment protocols.


Keywords: Chronic Myeloid Leukemia, Acute Myeloid Leukemia, lymphocytes, Imatinib mesylate, cytarabine, curcumin, Leukemia markers
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How to cite this article:

Apurba Mukherjee, Kalyan Kusum Mukherjee, Sutapa Mukherjee and Madhumita Roy. 2018. Curcumin May Enhance the Efficacy of Anti-Leukemia Drugs in Myeloid Leukemia.Int.J.Curr.Microbiol.App.Sci. 7(5): 3274-3283. doi: https://doi.org/10.20546/ijcmas.2018.705.383