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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(5): 2881-2891
DOI: https://doi.org/10.20546/ijcmas.2018.705.336


Clinical Importance of Emerging ESKAPE Pathogens and Antimicrobial Susceptibility Profile from a Tertiary Care Centre
Jagadevi, B. Saipriya*, D.S. Shubha, K.S. Sudhindra, A. Sumantha and K.R. Madhuri
Department of Microbiology, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, India
*Corresponding author
Abstract:

Bacterial species from the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) have high resistance rates by escaping the action of the antimicrobials and are responsible for two third of all health care associated infections. Aim of our study was to find out the bacterial profile and characterize the antimicrobial resistance in ESKAPE pathogens isolated from various specimens. A three year retrospective study was undertaken. Urine samples, pus/wound swabs, respiratory samples, blood samples received in the microbiology laboratory were included &processed as per standard techniques and bacteria identified. Antibiotic susceptibility was determined according to Clinical & Laboratory Standards Institute (CLSI) guidelines. 41.5% of S. aureus isolates were confirmed to be methicillin resistant and 5.9% vancomycin resistant enterococci (VRE) were identified. A high multidrug resistance was observed for Acinetobacter and P. aeruginosa than Enterobacteriaceae. For carbapenem group, resistance varied from 8 to 27%. Resistance to amikacin and netilmycin was lower (4-11%) for gram negative ESKAPE pathogens. Antimicrobial resistance surveillance reports on regular basis can provide valuable insight into resistance trends at a particular medical facility to assist in guidance in the appropriate choice of empiric therapy in diseases due to ESKAPE pathogens.


Keywords: Antimicrobial resistance, ESKAPE pathogens, Multidrug resistant (MDR) bacteria
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How to cite this article:

Jagadevi, B. Saipriya, D.S. Shubha, K.S. Sudhindra, A. Sumantha and Madhuri, K.R. 2018. Clinical Importance of Emerging ESKAPE Pathogens and Antimicrobial Susceptibility Profile from a Tertiary Care Centre.Int.J.Curr.Microbiol.App.Sci. 7(5): 2881-2891. doi: https://doi.org/10.20546/ijcmas.2018.705.336