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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(5): 2585-2589
DOI: https://doi.org/10.20546/ijcmas.2018.705.298


Antimicrobial Susceptibility Profile of E. coli Isolates Causing Urosepsis: Single Centre Experience
Pragya Agarwala1, Archa Sharma2* and Kamal Sharma3
1Department of Microbiology, All India Institute of Medical Sciences, Raipur, India
2Department of Microbiology, All India Institute of Medical Sciences, Bhopal, India
3Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, Gujarat, India, India
*Corresponding author
Abstract:

Urosepsis is defined as presence of systemic inflammatory response syndrome secondary to a severe infection of the urinary tract, with the risk of multi-organ dysfunction and shock. This study was designed to analyze the antimicrobial susceptibility profile of E. coli isolates causing urosepsis and to compare it with the susceptibility profile of other isolates of E. coli from blood stream infection. And to study the various factors associated with E. coli urosepsis cases. A total of 689 isolates of E. coli were isolated from blood cultures in 2015. Of them 112 were identified to be associated with urosepsis. The mean age of the urosepsis patients was 46.26 years (SD 17.24) and 65.1% were females. The prevalence of Extended spectrum beta lactamase production (ESBL), as screened by disc diffusion testing using ceftazidime was almost similar in the two groups, 76% in the isolates from urosepsis, and 72% in the other group (p value>0.05). Carbapenem resistance was found in 3.1% of urosepsis isolates. On the other hand, about 13% of the non urosepsis E. coli isolates carbapenem resistance (p value<0.05). We here with report high prevalence of ESBL production in blood stream E. coli isolates. In E. coli isolates associated with urosepsis, higher susceptibility towards aminoglycosides and carbapenems was seen. Thus these two groups can serve as empiric antibiotics of choice in a female patient with known predisposing factors for developing a UTI, and presenting with signs and symptoms of urosepsis.


Keywords: Antimicrobial Susceptibility, Urosepsis E. coli
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How to cite this article:

Pragya Agarwala, Archa Sharma and Kamal Sharma. 2018. Antimicrobial Susceptibility Profile of E. coli Isolates Causing Urosepsis: Single Centre Experience.Int.J.Curr.Microbiol.App.Sci. 7(5): 2585-2589. doi: https://doi.org/10.20546/ijcmas.2018.705.298