National Academy of Agricultural Sciences (NAAS)
|
PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
A simple, efficient and environmentally process for one pot three component synthesis of α-aminophosphonates by the condensation reaction of diversity of substituted benzaldehyde, amine and triethyl phosphite in the presence of microorganisms and yoghurt as a catalyst at room temperature under solvent free condition is described. The reaction was carried out using bacterial strains viz. Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus. Both the bacterial strains were equally efficient for the synthesis of α-aminophosphonates. Yoghurt containing both of these bacteria was found to be even more active as a catalyst in terms of reaction time. This green method provides α-aminophosphonates in good to excellent yields with high purity in very short reaction time. Molecular docking study was also done in order to further understand the increased catalytic activity of yoghurt as a function of microorganisms present in it. Interaction of substrate i.e. substituted benzaldehyde with crystal structure of dehydrogenase from Streptococcus thermophilus (PDB: 3DZB) and Lactobacillus delbrueckii ssp. bulgaricus (PDB: 2YQ4) was done to obtain moldock energy (kcal/mol).
Citations |
 |
 |
 |
 |
