National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Antimicrobial resistance is one of the major threats to human health. Thereby, discovering alternative strategies that can circumvent the mechanisms of resistance presents a big challenge. One of which is the use of nanotechnology and Photodynamic therapy. The current study included a total of 40 isolates that were; Twenty isolates of Staphylococcus aureus (14 MRSA and 6 MSSA isolates) and twenty isolates of multiple drug resistance (MDR) Gram negative bacteria (4 Escherichia coli, 4 Pseudomonas spp., 6 Klebsiella spp, 4 Proteus spp., 1 Acinetobacter spp. and one Enterobacter spp. isolates.). The effects due the interaction of silver nanoparticles (SNPs), laser in the presence of antibiotics (Polymyxin B for Gram negative bacteria and Fusidic acid for Gram positive bacteria) and photo-sensitizer; methylene blue (MB) on the test isolates was investigated by micro dilution test. The combinations that showed a statistically significant change in MIC values were those with the different combinations containing SNP. The effect of these combinations on the inhibition of growth of the Gram positive and/ or Gram negative isolates showed a statistically significant difference. In vivo studies are needed to determine whether considerable bacterial kills can be obtained in a wound model.
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