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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(4): 1301-1310
DOI: https://doi.org/10.20546/ijcmas.2018.704.145


Neonatal Septicemia: Bacteriology and Risk Factors in a Tertiary Care Hospital of Central India
J. Seth Riti* and Lazarus Monica
1Department of Microbiology
2Department of Pediatrics, NSCB Medical College, Jabalpur, India
*Corresponding author
Abstract:

Neonatal septicemia continues to be a major cause of mortality and morbidity among neonates around the world, in spite of great advances in antimicrobial therapy, neonatal life support measures and the early detection of risk factors. The present study was undertaken to describe the spectrum of isolates in cases of neonatal septicaemia, and their antimicrobial susceptibility pattern and to look for their association with various risk factors. In this prospective study in central India we prospectively enrolled the suspected cases of neonatal septicaemia, which were not on antimicrobials. One to two millilitre of blood from these neonates was cultured in brain heart infusion broth. Blood Culture and Antibiotic susceptibility testing were performed as per standard protocols. Detailed history and clinical findings were recorded. Data analysis was carried out using Statistical Package for Social Sciences for windows package. Out of 80 cases studied, bacterial growth was obtained in 41(51.25%) blood samples. The most frequent risk factor among neonates was low birth weight in both EOS and LOS groups. Septicemia was the most common cause of clinical presentation, followed by pneumonia and meningitis. Of the bacterial isolates, Klebsiella (46.3%), followed by S. aureus (29.2%) were the most common isolates. E. coli (9.7%), CONS (4.8%) and others like Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris and Citrobacter freundii were less frequent isolates. Among ALL isolates, resistance to penicillin and ampicillin was frequent. Case fatality rate (CFR) was SIGNIFICANTLY higher in the culture positive group. Sepsis with MODS was the most common causes of death in clinically suspected culture negative group, followed by sepsis with pneumonia. Here it is recommended that Perinatal risk score involving intrapartum risk factors should be used for triage of high risk babies and Choice of antibiotics should be based on routine surveillance of sensitivity pattern of particular organism.


Keywords: Neonatal septicaemia, Perinatal risk factors, Antimicrobial resistance, Gram negative septicaemia
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How to cite this article:

Seth Riti, J. and Lazarus Monica. 2018. Neonatal Septicemia: Bacteriology and Risk Factors in a Tertiary Care Hospital of Central India.Int.J.Curr.Microbiol.App.Sci. 7(4): 1301-1310. doi: https://doi.org/10.20546/ijcmas.2018.704.145