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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(4): 1265-1273
DOI: https://doi.org/10.20546/ijcmas.2018.704.141


Assessment of Genotoxic and Cytogenetic Effects of Aflatoxin B1 in Mouse Bone Marrow Cells
Awad A. Algarni*
Department of Biology, College of Science and Arts, Albaha University, Baljurashi, Saudi Arabia
*Corresponding author
Abstract:

Aflatoxin B1 (AFB1) is a widespread mycotoxin produced by toxicogenic Aspergillus species. AFB1 has been reported to cause harmful health effects, such as cancers and abnormal development and reproduction, in animals and humans. The current study was carried out to evaluate the genotoxic aspects of Aflatoxin B1 in the bone marrow cells obtained from Swiss albino mice, using chromosomal aberrations (CA), mitotic index (MI), and micronuclei (MN) formation as toxicological end points. Four groups of four mice each, weighing approximately 20-25 g, were orally administered once a day for 30 days with doses of 1, 2, 4, 8 and 16 mg/kg BW of AFB1. The control group was made up of four animals orally administered with Deionized water. AFB1 exposure significantly increased the number of CA and the frequency of micronucleated cells and decreased the mitotic in treated groups when compared with the control group. This significant increase in CAs as well as micronuclei formation induced by AFB1 may be attributed to the fact that AFB1 can induce genotoxicity through DNA damage. Thus, the present study indicates that AFB1 was genotoxic in vivo in bone-marrow cells of mice.


Keywords: Aflatoxin B1, Mycotoxin, Genotoxicity, Mutagenicity, DNA Damage, Chromosome Aberrations, Mitotic index, Micronuclei induction
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How to cite this article:

Awad A. Algarni. 2018. Assessment of Genotoxic and Cytogenetic Effects of Aflatoxin B1 in Mouse Bone Marrow Cells.Int.J.Curr.Microbiol.App.Sci. 7(4): 1265-1273. doi: https://doi.org/10.20546/ijcmas.2018.704.141