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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(8): 3367-3373
DOI: https://doi.org/10.20546/ijcmas.2017.608.459


In Vitro Cytotoxic Activity of Leaf Extracts of Selected Medicinal Plants
B. Kalpana1 and M. Prakash2*
1Research & Development Centre, Bharathiar University, Coimbatore-641 046, Tamil Nadu, India
2Department of Microbiology, Kanchi Shri Krishna College of Arts and Science, Kilambi, Kancheepuram-631 551, Tamil Nadu, India
*Corresponding author
Abstract:

In the present study the ethanol extracts of Capparis sepiaria, Euphorbia heterophylla and Tamilnadia uliginosa leaf were tested for cytotoxic activity against three different human cancer cell lines such as HeLa cervical cancer cell line, MCF-7 human breast adenocarcinoma cell line and A-549 Human lung adenocarcinoma epithelial cell line, and compared with vero normal cell line. These studies revealed that Tamilnadia uliginosa crude extracts exhibited potent cytotoxic activity towards A-549 cell line with CTC50 value of 164.3 µg/ml followed by 179.4 µg/ml against MCF-7 cell lines and 208.2 µg/ml against HeLa cell lines. The leaf extracts of Euphorbia heterophylla showed least cytotoxicity against the tested cell lines. The results indicate the feasible anticancer nature of the crude ethanolic extract of Tamilnadia uliginosa leaves.


Keywords: Leaf extract, Medicinal plants, Cytotoxic activity, Cell lines
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How to cite this article:

Kalpana B. and Prakash M. 2017. In Vitro Cytotoxic Activity of Leaf Extracts of Selected Medicinal Plants.Int.J.Curr.Microbiol.App.Sci. 6(8): 3367-3373. doi: https://doi.org/10.20546/ijcmas.2017.608.459