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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 824-835
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.095


Role of Chymases in Human Biology: Significance, Mechanism and Functions
D.B.M. Virupakshaiah* and Asiya Rozindar
 Department of Biotechnology Basaveshwar Engineering College, Bagalkot, India
*Corresponding author
Abstract:

Chymases belong to family of serine proteinases that are abundantly produced by mast cells in the blood vessels and the myocardium, Recent biochemical reports suggested that chymase is involved in a number of important physiological processes, such as inflammation, stimulation of sub mucosal gland secretion, processing of hormones and cytokines, release of growth factor, parasite expulsion and tissue remodeling. They show broad peptidolytic activity and are involved in a variety of functions. Chymase provides an important mechanism to maintain steady state AngII concentration in tissues but not in plasma. The review also gives information regarding various roles of chymase and its significance in heart modelling, chymase is a plays important role in inflammation and remodeling in the asthmatic lung. Chymase  is   the  major  chymotryptic  proteinase  of  human  mast  cells,  can  be  released  in  substantial  quantities  by  mast  cell activation,Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet . chymase as an important target for preventing complications of metabolic syndrome .Chymase plays a crucial role in angiotensin II formation in various tissues. Chymase converts angiotensin I to angiotensin II and it can also convert precursors of TGF-β and MMP-9 to their active forms.Chymase has various applications few are mentioned in this review.


Keywords: Chymases, Angiotensin-II, remodeling, inflammation, proteinase.
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How to cite this article:

Virupakshaiah, D.B.M., and Asiya Rozindar. 2016. Role of Chymases in Human Biology: Significance, Mechanism and FunctionsInt.J.Curr.Microbiol.App.Sci. 5(7): 824-835. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.095