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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(3): 3178-3186
DOI: https://doi.org/10.20546/ijcmas.2018.703.367


Effects of Ethanol Extract of Cola lepidota Seed on Lipid Profile and Haematological Parameters of Albino Wistar Rats
C.N. Ekweogu1, P. Nwankpa1, J.N. Egwurugwu2, C.C. Etteh1, P.C. Ugwuezumba2 and O.G. Chukwuemeka3
1Department of Medical Biochemistry
2Department of Medical Physiology, Imo State University, Owerri, Nigeria
3Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Nigeria
*Corresponding author
Abstract:

This study was conducted to evaluate the effects of ethanol seed extract of Cola lepidota (Monkey kola) on lipid profile and haematological parameters of albino wistar rats. Twenty eight (28) adult albino wistar rats weighing between 170g-200g were randomly divided into four groups of 7 rats each. The control group (I) was fed with normal rat chow ad libitum. Group II received daily oral dose of 100mg/kg of the extract, Group III received daily oral dose of 200mg/kg of extract while Group IV received daily oral dose of 300mg/kg. After 21 days of treatment, the animals were sacrificed and plasma obtained for haematological assay and lipid profile determination. Results indicated that there was a significant decrease (p<0.05) in total cholesterol (mmol/L), triglyceride (mmol/L) and low density lipoprotein (mmol/L) in test groups compared to control. The result showed a significant increase (p<0.05) in packed cell volume (%), haemoglobin (g/dl), mean corpuscular volume (fl), mean corpuscular haemoglobin (pg), WBC count (µL), platelet count (µL). There was however a significant decrease (p<0.05) in mean corpuscular haemoglobin concentration (g/ml) compared to control. It was therefore concluded that the extract is capable of stimulating haematopoeisis and is a potent antihyperlipidaemic agent and should therefore be used in the management of cardiovascular disease risk factors.


Keywords: Cola lepidota, Antihyperlipidaemic, Haematopoeisis, Wistar rats
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How to cite this article:

Ekweogu, C.N., P. Nwankpa, J.N. Egwurugwu, C.C. Etteh, P.C. Ugwuezumba and Chukwuemeka, O.G. 2018. Effects of Ethanol Extract of Cola lepidota Seed on Lipid Profile and Haematological Parameters of Albino Wistar Rats.Int.J.Curr.Microbiol.App.Sci. 7(3): 3178-3186. doi: https://doi.org/10.20546/ijcmas.2018.703.367