National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Edwardsiella tarda is a Gram negative bacterium with a wide host range, mainly affecting fishes. It is a dreaded pathogen of cat fish culture. The presence of large number of serotypes of the pathogen makes the vaccine production against the pathogen a difficult task. Here in this study the suitability of outer membrane protein W (OMP W) as a vaccine candidate against E. tarda was investigated. OMPs has the characteristics of localization in the outer membranes of Gram negative bacteria, which make them easily accessible to the host antibody there by triggering an antigen antibody reaction in the host body. The 3D structure of the protein was constructed using homology modeling, the quality of the model was evaluated and finally the factors for a biological molecule to be considered as a vaccine candidate were being checked for the OMP. The solvent accessible regions, the antigenic regions, epitope positions were found out. Further the domains, patterns, motifs detected together with the fact that OMP W is an adhesin strongly suggest OMP W of E. tarda as a potential vaccine candidate.
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