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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(3): 2762-2773
DOI: https://doi.org/10.20546/ijcmas.2018.703.319


In Silico Homology Modeling and Epitope Prediction of Outer Membrane Protein OMP W, A Potential Vaccine Candidate against Edwardsiella tarda
M. Neema1* and I. Karunasagar2
1Division of Crop Improvement, ICAR-Central Plantation Crop Research Institute, Kasaragod, Kerala-671 124, India
2UNESCO MIRCEN for Marine Biotechnology, Nitte University Centre for Science Education and Research, Paneer Campus, Deralakatte, Mangalore 575018, India
*Corresponding author
Abstract:

Edwardsiella tarda is a Gram negative bacterium with a wide host range, mainly affecting fishes. It is a dreaded pathogen of cat fish culture. The presence of large number of serotypes of the pathogen makes the vaccine production against the pathogen a difficult task. Here in this study the suitability of outer membrane protein W (OMP W) as a vaccine candidate against E. tarda was investigated. OMPs has the characteristics of localization in the outer membranes of Gram negative bacteria, which make them easily accessible to the host antibody there by triggering an antigen antibody reaction in the host body. The 3D structure of the protein was constructed using homology modeling, the quality of the model was evaluated and finally the factors for a biological molecule to be considered as a vaccine candidate were being checked for the OMP. The solvent accessible regions, the antigenic regions, epitope positions were found out. Further the domains, patterns, motifs detected together with the fact that OMP W is an adhesin strongly suggest OMP W of E. tarda as a potential vaccine candidate.


Keywords: In Silico, Epitope, Outer membrane protein, Edwardsiella tarda
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How to cite this article:

Neema, M. and Karunasagar, I. 2018. In Silico Homology Modeling and Epitope Prediction of Outer Membrane Protein OMP W, A Potential Vaccine Candidate against Edwardsiella tarda.Int.J.Curr.Microbiol.App.Sci. 7(3): 2762-2773. doi: https://doi.org/10.20546/ijcmas.2018.703.319