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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(3): 988-994
DOI: https://doi.org/10.20546/ijcmas.2018.703.117


Bacteriological Profile of Hospital Acquired Infections with Multidrug Resistance Burden and Extended Spectrum Beta Lactamase Prevalence
Tarana Sarwat*, Vichal Rastogi, Mohd. Rashid and Yogesh Chander
Department of Microbiology, SMS&R, Sharda University, Greater Noida, India
*Corresponding author
Abstract:

Hospital acquired infections are one of the major causes of morbidity and mortality in hospitalized patients, leading to an enormous increase in the cost of hospital care and to the emergence of new health hazards for the community. The study aimed to determine the bacteriological profile of hospital acquired infections along with prevalence of multidrug resistance and extended spectrum beta lactamase (ESBL) enzymes amongst the isolates. A total of 180 isolates of various organisms were isolated from different clinical samples during a period of one year from January 2014 to December 2014. The antibiotic susceptibility testing of the isolates was done on Mueller Hinton agar using antibiotics from different classes which included beta lactams, aminoglycosides, macrolides and fluoroquinolones. Multidrug resistance was defined as resistance of the isolate to three or more classes of antibiotics. Extended spectrum beta lactamase detection was done in Gram negative isolates by the combined disc diffusion method. The isolates included Staphylococcus aureus (32.22%), Pseudomonas aeruginosa (20.56%), Escherichia coli (16.11%), Coagulase negative Staphylococcus (12.22%), Klebsiella pneumoniae (8.89%), Acinetobacter sp. (5.56%), Enterococcus sp. (2.78%) and Proteus mirabilis (1.67%). Out of these 180 isolates, 27 (15%) isolates were found to show multidrug resistance, Pseudomonas aeruginosa and Acinetobacter being the major multidrug resistant organisms. Out of the 95 Gram negative organisms, 39 were confirmed to be ESBL producers by phenotypic method. The study concluded that the hospital strains of microorganisms are becoming more and more resistant to the currently available antibiotics. So, the antibiotics should be used more judiciously keeping the higher antibiotics in reserve which can be a solution to multidrug resistance.


Keywords: Hospital acquired infections, Multidrug resistance, Extended spectrum beta lactamases, Non- fermenters
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How to cite this article:

Tarana Sarwat, Vichal Rastogi, Mohd. Rashid and Yogesh Chander. 2018. Bacteriological Profile of Hospital Acquired Infections with Multidrug Resistance Burden and Extended Spectrum Beta Lactamase Prevalence.Int.J.Curr.Microbiol.App.Sci. 7(3): 988-994. doi: https://doi.org/10.20546/ijcmas.2018.703.117