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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(3): 722-727
DOI: https://doi.org/10.20546/ijcmas.2018.703.084


Diagnostic Value of C - Reactive Protein and Hematological Markers in Neonatal Sepsis
D. Jeyaganguli*, G. Velvizhi, G. Sucilathangam and C. Revathy
Department of Microbiology, Tirunelveli Medical College, Tirunelveli - 627 011, Tamil Nadu, India
*Corresponding author
Abstract:

Sepsis is a major problem in neonates. Clinical criteria alone could not establish the diagnosis of neonatal sepsis. It is extremely important to make an early diagnosis of neonatal sepsis for the prompt institution of anti-microbial therapy, which improves outcomes. The aim of this study is to determine the diagnostic performance of C - reactive protein (CRP) as early diagnostic marker in detection of neonatal sepsis in intensive neonatal care unit in comparison to that of blood culture and Hematological parameters like micro ESR and Total WBC count. This prospective study was conducted on neonates admitted to neonatal intensive care unit (NICU) at Tirunelveli Medical College Hospital, Tirunelveli, Tamil Nadu. Blood specimens (n = 60) were obtained from each neonate prior to commencement of antibiotics for sepsis work up including Hematological parameters like micro ESR, Total leukocyte count, absolute Neutrophil count (ANC), immature neutrophils to Total Neutrophil count ratio (I/T ratio). Blood culture was carried out by conventional method. Serum CRP level was measured by latex agglutination method. As per present study the sensitivity of CRP in predicting sepsis was 73.1 %, its specificity was 60%, its positive predictive value was 57.6 % and its negative predictive value was 77 %. P value of the test applied for statistical significance is less than 0.0001 which is statistically significant for CRP. Results of the current study indicate that despite the continuing emergence of newer markers of sepsis, CRP still plays a central role in the diagnosis of neonatal sepsis.


Keywords: Neonatal sepsis, C - reactive protein (CRP), Blood culture, Hematological parameters
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How to cite this article:

Jeyaganguli, D., G. Velvizhi, G. Sucilathangam and Revathy, C. 2018. Diagnostic Value of C - Reactive Protein and Hematological Markers in Neonatal Sepsis.Int.J.Curr.Microbiol.App.Sci. 7(3): 722-727. doi: https://doi.org/10.20546/ijcmas.2018.703.084