National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Neonatal septicemia remains one of the most important causes of mortality despite considerable progress in hygiene, introduction of new antimicrobial agents and advanced measures for early diagnosis and treatment. Septicemia in neonates refers to generalized bacterial infection documented by positive blood culture in the first four weeks of life. To isolate and identify the bacterial etiologic agents responsible for neonatal sepsis and determine the antibiotic susceptibility pattern of isolates in a tertiary care hospital in Greater Noida, Western U.P. Blood samples from the suspected infants were collected and processed in the bacteriology laboratory. The growth was identified by standard microbiological protocol and the antibiotic sensitivity testing was carried out on MHA by Kirby-Bauer disk diffusion method as recommended in CLSI guidelines. Out of the 147 suspected blood culture samples, 52 (35.4%) shows blood culture positive. 46 (88.5%) had Gram positive and 6 (11.5%) neonates had Gram negative septicemia. 31 (59.6%) cases were due to early onset septicemia. CoNS (55.8%) was the predominant Gram positive organism and Klebsiella species (7.7%) was the predominant Gram negative organism Best overall sensitivity among Gram positive isolates was to vancomycin (100%) and linezolid (100%) followed by amikacin (93.3%) and ciprofloxacin (63%). Gram negative isolates demonstrated highest sensitivity against imipenem (100%) and ciprofloxacin (100%) followed by meropenem (83.3%) and amikacin (83.3%). The result of our study reveals that the CoNS, Staphylococcus aureus and Klebsiella pneumoniae are the most common etiological agents of neonatal septicemia. In particular, since rate of CoNS causing sepsis is alarming, prompting concern to curb the excess burden of CoNS infection is necessary.
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