National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Keratin pearl (KP) and individual cell keratin(ICK) observation is one of the criteria in grading oral squamous cell carcinoma(SCC). The aim of the study was to evaluate and compare the distinct staining and identification of KP and ICK by routine Hematoxylin & Eosin (H&E) stain and Modified Papanicolaou (PAP) Stain. A total number of 38 paraffin embedded tissues of known cases of well-differentiated and moderately-differentiated SCC were taken and 2 sections of 4-5 micron thickness from each block were cut and stained with H&E stain and modified PAP stain. The KP and ICK were distinctly and clearly stained by modified PAP compared to H&E stain. The positive staining of KP and ICK by modified PAP was statistically significant with P=0.001, f=0.001 and P=0.022, f=0.034 than H&E stain. Based on our findings we conclude that the efficacy of distinct identification of KP and ICK in oral SCC by modified PAP stain is better than H&E stain. So it can be used as an adjuvant in case of oral SCC.
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