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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 474-481
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.051


Mitochondrial Biogenesis in Heart: Way of Nurturing and Failure
Swati Sharma* and Abha Swarup
 Department of Zoology and Applied Aquaculture, Barkatullah University, Bhopal, India
*Corresponding author
Abstract:

Mitochondria is the key organelle of cell which provide energy output for various functions and mechanisms inside the cell with the production of ATP and it is directly linked to the protection from chronic diseases such as neurodegenerative diseases, heart disease, diabetes and metabolic syndrome. Its biogenesis get affected by the alterations in both nuclear and mitochondrial DNA (mtDNA) due to the improper oxidative phosphorylation process. One possible approach to relieve this deficiency might be to boost the residual OXPHOS capacity by increasing the mitochondrial functional mass in the affected tissues. Heart is the organ which continuously contract and pump blood to whole body and this contraction is maintained by energy output from mitochondria. So the biogenesis and mechanisms of mitochondria is directly proportional to the working capacity and quality of heart health. Current treatments for heart disease address the symptoms of deficiency but not the cure. One possible approach to relieve the deficiency might be to boost the residual OXPHOS capacity by increasing the mitochondrial functional mass in the affected tissues which leads to the proper biogenesis of mitochondria and heart function.


Keywords: Mitochondria, Neurodegenerativediseases, OXPHOS, Biogenesis,Heart failure.
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How to cite this article:

Swati Sharma and Abha Swarup. 2016. Mitochondrial Biogenesis in Heart: Way of Nurturing and Failure.Int.J.Curr.Microbiol.App.Sci. 5(7): 474-481. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.051