National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The Hallmark of Autoimmune diseases is the pathologic activity of the immune system of an organism directed against its own cells and tissues. The disease is a direct consequence of tissue and/or organ damage as mediated by auto reactive components of the immune system, that is, auto reactive T lymphocytes and/or auto antibodies. For diagnostic purposes, auto antibodies are the most important analytes. Current clinical practice considers Antinuclear Antibody (ANA) testing as a screening test; this has a major impact on laboratory work with a growing volume of analyses that need to be performed rapidly, to maintain good specificity and sensitivity. The present study was undertaken to determine the rate of ANA positivity and their relationship with the various patterns of the positive specimens. In the present study, a total of 558 samples from patients with clinical suspicion of autoimmune diseases were collected during the period of 2016-17 and was tested for ANA by Indirect Immunofluorescence(IIF) with standard procedures. A total of 558 samples were collected and out of which 76(13.6%) were positive for Antinuclear antibodies with the positivity significantly higher in females. Among the positives, most commonly observed pattern was coarse speckled in 27 cases (35.5%). Information about the pattern types and the distribution of the patterns contribute in diagnosis of autoimmune diseases. It is observed that clinical diagnosis has been supported significantly by ANA test according to data of the present study.
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