National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Resistance to carbapenems is an emerging problem among Klebsiella pneumoniae isolates. A simple and effective phenotypic detection method for carbapenemase production is required in health care settings. A total of 100 clinical isolates of Klebsiella pneumoniae from various samples were screened for imipenem resistance. The imipenem resistant strains were further tested for metallo-beta-lactamase (MBL) production by imipenem combined disc test and ceftazidime combined disc test. Among the 100 isolates, 62 isolates were imipenem resistant and of these 45 were MBL producers. Ceftazidime combined disc method alone could detect 24 (53.3%), imipenem combined disc method alone could detect 12 (26.6%) and nine (20%) of the isolates were positive by both these methods. The present study highlights the burden of MBL producing Klebsiella pneumoniae in a North Indian tertiary care hospital. The study findings suggest that using ceftazidime combined disc test alone had a better yield of MBL when compared to imipenem combined disc test alone. However, combination of both the methods resulted in greater detection of MBL production.
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