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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(2): 2618-2631
DOI: https://doi.org/10.20546/ijcmas.2018.702.319


Diagnostic Value of Ascitic Fluid Lactoferrin, Calprotectin, and Calprotectin to Albumin Ratio in Spontaneous Bacterial Peritonitis
N.A. Makhlouf1*, K.H. Morsy2, A.A. Mahmoud3 and A.E. Hassaballa3
1Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
2Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt
3Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt
*Corresponding author
Abstract:

Spontaneous bacterial peritonitis (SBP) is common and dangerous infection that occurs in 8-27% of cirrhotic inpatients with ascites. In the current study we have demonstrated and compared the diagnostic performance of ascitic fluid lactoferrin and calprotectin in the screening and diagnosis of SBP. In addition we have evaluated ascitic fluid calprotectin to albumin ratio as a novel marker in the diagnosis and Prognosis of SBP. In this cross sectional analytic study, ascitic fluids were collected from 87 cirrhotic patients (49 with SBP and 38 without SBP. Calprotectin and lactoferrin were measured in the ascitic fluids by quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Ascitic fluid calprotectin and lactoferrin were increased significantly in SBP group when compared with non SBP group. Moreover, they were corre¬lated in a positive manner with white blood cells (WBCs) count in ascitic fluid, Polymorphnuclear cells (PMN) count, and serum C-reactive protein (CRP). Also, calprotectin to albumin ratio was increased in SBP cases versus non SBP cases. Moreover, calprotectin to albumin ratio was significantly higher among SBP patients who died inside the hospital than patients with SBP who survived. Both ascitic fluid lactoferrin and calprotectin can be used as valuable markers for diagnosis of SBP. However, ascitic fluid calprotectin is more sensitive and more specific than lactoferrin for diagnosis of SBP. Moreover, calprotectin to albumin ratio in ascites is useful in the diagnosis for SBP as well as it provides prognostic information about the in hospital mortality.


Keywords: Calprotectin, Lactoferrin, Liver cirrhosis, Spontaneous bacterial peritonitis, Prognostic marker
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How to cite this article:

Makhlouf, N.A., Morsy, K.H., Mahmoud, A.A., and Hassaballa, A.E. 2018. Diagnostic Value of Ascitic Fluid Lactoferrin, Calprotectin, and Calprotectin to Albumin Ratio in Spontaneous Bacterial Peritonitis.Int.J.Curr.Microbiol.App.Sci. 7(2): 2618-2631. doi: https://doi.org/10.20546/ijcmas.2018.702.319