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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(2): 1662-1667
DOI: https://doi.org/10.20546/ijcmas.2018.702.201


Antimicrobial Resistance Pattern of Pseudomonas aeruginosa of Various Clinical Samples in Government Medical College, Aurangabad, India
Shaikh Ambreen Fatema Abdul Hafiz, Anil A. Gaikwad*, J.A. Iravane, Harbade (Duthade) and A.S. Damle
Department of Microbiology, Government Medical College, Aurangabad, India
*Corresponding author
Abstract:

In this era spread of multidrug resistance is a global problem. P. aeruginosa is one of the most common nosocomial pathogen causing wide range of opportunistic infections. Rapid emergence of varying degrees of innate & acquired resistance mechanisms has put forward a major challenge in their detection as well as treatment options. We did a prospective study, from January 2016 to December 2016, in Department of Microbiology at Government Medical College, Aurangabad. Out of 3,340 culture positive samples, 676 (20.23%) were identified as P. aeruginosa by standard bacteriological identification methods, from various specimens. Antimicrobial sensitivity testing was done by Modified Kirby-Bauer disc diffusion method as per CLSI guidelines 2016. Results showed maximum antibiotic resistance to Nalidixic acid (100%), Ampicillin (83.3), Ceftriaxone (72.8%), Nitrofurantoin (72%), Cefepime (62.9%), Norfloxacin (65.2%), Cefotaxime (57.6%), Ceftazidime (56.1%) against Colistin (94.9%), Amikacin (93.9%), Piperacillin/Tazobactam (94.3%), Imipenem (82.2%), Cefoxitin (67.6%) Ceftazidime/Clavulanic acid (57.9%) which were identified as the most effective antibiotics. Prevalence of ESBL, AmpC and MBL producers was found to be 21.74%, 10.62% and 9.31% respectively. Conclusion: Emerging multi drug resistant P. aeruginosa needs inevitable screening and confirmation for β - lactamases production so that proper treatment can be initiated with appropriate antibiotics for commendable outcome, further their spread can be prevented by applying infection control policy and judicious use of antibiotics in the hospital.


Keywords: Pseudomonas aeruginosa (P. aeruginosa), ESBL, AmpC, MBL
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How to cite this article:

Shaikh Ambreen Fatema Abdul Hafiz, Anil A. Gaikwad, J.A. Iravane, Harbade (Duthade) and Damle, A.S. 2018. Antimicrobial Resistance Pattern of Pseudomonas aeruginosa of Various Clinical Samples in Government Medical College, Aurangabad, India.Int.J.Curr.Microbiol.App.Sci. 7(2): 1662-1667. doi: https://doi.org/10.20546/ijcmas.2018.702.201