National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Urinary tract infections (UTI) are one of the most frequent problems in hospitalized patients. Infections caused by the gram-negative bacteria which produces Extended-spectrum β-lactamases (ESBL) have become the severe problem in the hospitals across the globe. Increase in extended-spectrum beta-lactamase producing organisms in recent years has led to the limitation of treatment option. This study was designed to evaluate the occurrence of different uropathogens producing ESBL, its antibiogram and Multi-drug resistance (MDR) status in hospitalized patients. 885 non-repetitive urine samples were collected in the study. A total of 293 (33.11%) samples showed significant bacteriuria. Females were found to be more infected as compared to males. The senior citizens were found to be most affected (>60 years). The most common ESBL producing uropathogens were Escherichia coli (E. coli) followed by Klebsiella pneumoniae (K. pneumoniae). All the ESBL positive isolates were found to be MDR. The prevalence of MDR was also significantly increased due to ESBL production. The monitoring of antibiotic resistance and susceptibility of bacterial strains should be mandatory due to the higher frequency of the ESBL producing uropathogens found in the hospitalized patients. It was proved in this study that the multi-drug resistance was responsible for the significant treatment failure. Hence testing of ESBL production in the uropathogens is warranted. It is also suggested not to prescribe any antibiotics without undertaking the culture and sensitivity report as it may further erode the antibiotics sensitivity in the studied regional population.
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