National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
In recent years, naturally derived metabolites are main target for the treatment of various biological disorders. It is highly used in the medicinal chemistry to avoid side effects in the treatment. In this context, our research focused to derive antibacterial and antioxidant properties from the algal metabolites. Marine algal species such as Chlorella salina, Nannochloropsis oculata, Dunaliella salina and Isochrysis galbanaare focused. The algal species were inoculated in Artificial and F2 natural sea water media. The growth rate was monitored dailyin the media. The maximum growth rate of the algal species was obtained at 10-12 days of incubation time. Mass multiplication was done at small scale reactor vessel (60L) to get the maximum yield of biomass. The extracted biomass was dried and used in antibacterial and antioxidant assays. Antibacterial activity done on the four different human pathogens namely Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Proteus vulgaris. The highest inhibitory activity was found in Dunaliella salina. Further, antioxidant potential was done from the potential extract in which Dunaliella salina exhibited the highest activity in DPPH as well as FRAP assays. Inhibitory concentration (IC50) of Dunaliella salina was calculated as 80μg/ml whereas Isochrysis galbana was observed as 100 μg/ml. Moreover, chlorophyll, carotenoids and total phenolic content was studied. Results of GC – MS that the crude extracts showed that the crude extract of Dunaliella salina contain Triclosan, Dodecane and α-Amyrin which are nowadays used as drug ingredients for the treatment of cancer.
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