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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 253-266
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.026


Invitro Assessment of Antimicrobial and Antioxidant Activity of Bioactive Compounds from Marine Algae
S.Rubavathi* and M. Ramya
Department of Biotechnology, KSR College of Technology, Tamilnadu, India
*Corresponding author
Abstract:

In recent years, naturally derived metabolites are main target for the treatment of various biological disorders. It is highly used in the medicinal chemistry to avoid side effects in the treatment. In this context, our research focused to derive antibacterial and antioxidant properties from the algal metabolites. Marine algal species such as Chlorella salina, Nannochloropsis oculata, Dunaliella salina and Isochrysis galbanaare focused. The algal species were inoculated in Artificial and F2 natural sea water media. The growth rate was monitored dailyin the media. The maximum growth rate of the algal species was obtained at 10-12 days of incubation time. Mass multiplication was done at small scale reactor vessel (60L) to get the maximum yield of biomass. The extracted biomass was dried and used in antibacterial and antioxidant assays. Antibacterial activity done on the four different human pathogens namely Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Proteus vulgaris. The highest inhibitory activity was found in Dunaliella salina. Further, antioxidant potential was done from the potential extract in which Dunaliella salina exhibited the highest activity in DPPH as well as FRAP assays. Inhibitory concentration (IC50) of Dunaliella salina was calculated as 80μg/ml whereas Isochrysis galbana was observed as 100 μg/ml. Moreover, chlorophyll, carotenoids and total phenolic content was studied. Results of GC – MS that the crude extracts showed that the crude extract of Dunaliella salina contain Triclosan, Dodecane and α-Amyrin which are nowadays used as drug ingredients for the treatment of cancer.


Keywords: Biomass,Bioactive potential, Inhibition, Antioxidant activity, Drug Ingredients.
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How to cite this article:

Rubavathi, S., and Ramya, M. 2016. Invitro Assessment of Antimicrobial and Antioxidant Activity of Bioactive Compounds from Marine Algae.Int.J.Curr.Microbiol.App.Sci. 5(7): 253-266. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.026