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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(2): 1114-1126
DOI: https://doi.org/10.20546/ijcmas.2018.702.139


Significance of Regional Antibiogram and MDR of ESBL Producing Uropathogens Infecting Non-hospitalized Patients: Gurugram
Rishabh Rajput1,2* and Surendra Sarsaiya1,3
1Department of Microbiology, Sri Satya Sai University of Technology and Medical Sciences, Sehore-Madhya Pradesh, India
2Department of Microbiology, Modern Diagnostic and Research Centre, Gurugram, Haryana, India
3Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, China
*Corresponding author
Abstract:

Worldwide, UTI is found to be the second most common form of infection ranging from neonate to geriatric age group, accounting for nearly 25% of all infections. It is the most common infection experienced by humans after respiratory and gastrointestinal infections Increase in extended-spectrum beta-lactamase (ESBL) producing organisms in recent years has led to the limitation of treatment option. This study was focused to investigate the prevalence of different uropathogens producing ESBL and its antibiogram in non-hospitalized patients. 1495 non-repetitive urine samples were collected in the study. A total of 335 (22.41%) samples showed significant bacteriuria. Females were found to be more infected as compare to Males. The most affected age group was ≥ 60 years. The most common ESBL producing uropathogens were E. coli followed by Klebsiella pneumoniae. All the ESBL positive isolates were found to be Multi-Drug resistant (MDR). The prevalence of MDR was also significantly increased due to ESBL production. International guidelines are no longer applicable for treating UTIs in India and development of specific guidelines based on local susceptibility patterns is an absolute necessity and researchers need to keep monitoring on the ever-changing trend in the antibiotic susceptibility pattern of ESBL positive and negative isolates in our region and facilitate evidence-based judicious antibiotic use policy to treat UTI. Every healthcare setup should have their antibiogram policy to enable them to choose the right antibiotics as per the trend going in the particular area and should stop prescribing antibiotics without the culture and sensitivity test report.


Keywords: UTI, Multi-drug resistant, Extended-spectrum β-lactamase, ESBL, E. coli, K. pneumoniae, CLSI, ATCC
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How to cite this article:

Rishabh Rajput and Surendra Sarsaiya. 2018. Significance of Regional Antibiogram and MDR of ESBL Producing Uropathogens Infecting Non-hospitalized Patients: Gurugram.Int.J.Curr.Microbiol.App.Sci. 7(2): 1114-1126. doi: https://doi.org/10.20546/ijcmas.2018.702.139