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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(2): 911-920
DOI: https://doi.org/10.20546/ijcmas.2018.702.115


Microbiological Profile of Urinary Tract Infections with special Reference to Antibiotic Susceptibility Pattern of Escherichia coli Isolates
Eman Elsayed Hegazy1*, Rasha Abd El-Hamid Alam El-Din1, Ahmed Mostafa Amin1, Fawkia Mohamed Mahgoub1 and Samir Abd El-Hakeem El-Gamal2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Tanta University, Egypt
2Urology Department, Faculty of Medicine, Tanta University, Egypt
*Corresponding author
Abstract:

Urinary tract infections, caused by multidrug resistant uropathogenic Escherichia coli (UPEC) are alarmingly escalating. Widespread utilization of empirical antibiotics without performing anti-microbial susceptibility testing led to expanding resistance to different classes of antimicrobial agents generally prescribed among UPEC isolates in our country. Therefore, this study aims to detect the prevalence and the antibiotic susceptibility pattern of UPEC isolates, in Tanta University Hospitals, Egypt. A total of 200 urine samples were collected from July 2015 to August 2016. Urine count and culture were done. Antibiotic susceptibility testing was performed according to the clinical and laboratory standards institute guidelines (CLSI 2016).E. coli was the predominant isolate (53.85%) followed by Klebsiella spp. (17.58%), Candida spp (10.99%), Proteus spp. (6.04%) Coagulase negative Staphylococcus (3.85%) Enterococcus spp. (2.75%), Pseudomonas spp. (2.19%), Acinetobacter baumannii (1.65%), Enterobacter spp. (0.55%) and Serrate marascences (0.55%). The highest percentage of UPEC isolates were non susceptible to Ampicillin, Cefazolin (100%) for each, followed by Nalidixic acid (91.84%), Trimethoprim/sulfamethoxazole (87.9%), Norfloxacin (82.65%), beta-lactam inhibitors (81.3%), Ceftriaxone (79.60%), Cefotaxime (74.49%), Ceftazidime (64.3%), Gentamicin (26.53%), Amikacin (22.45%), Nitrofurantoin (21.4%) and Imipenem (20.41%). Therefore, physicians must follow antibiotic stewardship and change their treatment pattern based on performing antibiotic susceptibility testing.


Keywords: Urinary tract infections Uropathogenic E. coli, Antimicrobial resistance, Antibiotic susceptibility, Antibiotic stewardship
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How to cite this article:

Eman Elsayed Hegazy, Rasha Abd El-Hamid Alam El-Din, Ahmed Mostafa Amin, Fawkia Mohamed Mahgoub and Samir Abd El-Hakeem El-Gamal. 2018. Microbiological Profile of Urinary Tract Infections with special Reference to Antibiotic Susceptibility Pattern of Escherichia coli Isolates.Int.J.Curr.Microbiol.App.Sci. 7(2): 911-920. doi: https://doi.org/10.20546/ijcmas.2018.702.115