Follow
International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

Login as a Reviewer

Indexed in



National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

See Guidelines to Authors
Current Issues

Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(2): 513-522
DOI: https://doi.org/10.20546/ijcmas.2018.702.065


Evaluation of Prevalence of Inducible Clindamycin Resistance among Coagulase Negative Staphylococci (CoNS) Isolated from Various Clinical Samples in a Tertiary Care Hospital of North India
Razia Khatoon1 and Noor Jahan2*
1Department of Microbiology, Hind Institute of Medical Sciences, Mau, Ataria, Sitapur-261303, India
2Department of Microbiology, Integral Institute of Medical Sciences and Research, Integral University, Lucknow-226026, India
*Corresponding author
Abstract:

Coagulase-negative Staphylococci (CoNS) have emerged as predominant pathogens in hospital and community acquired infections. Clindamycin is a good therapeutic agent in treatment of skin, soft tissue as well as serious infections caused by both methicillin sensitive and resistant Staphylococci. However, strains with inducible clindamycin resistance often lead to therapeutic failure. Hence, each laboratory should be aware of the local prevalence of this resistance among clinical staphylococcal isolates. Therefore, the present study was done to evaluate the prevalence of inducible clindamycin resistance among CoNS isolates. A total of 152 CoNS isolated from clinical samples were evaluated for antimicrobial susceptibility testing using Kirby Bauer disk diffusion method and simultaneously D-zone test was interpreted by putting clindamycin and erythromycin disks adjacent to each other. Out of 152 CoNS isolates tested, 38.8% were methicillin resistant (MRCoNS) and 61.2% were methicillin sensitive (MSCoNS), with 33.6% hospital acquired strains and 66.4% community acquired strains. The prevalence of inducible clindamycin resistance was found to be 14.5%, with higher prevalence among MRCoNS (20.3%) as compared to MSCoNS (10.8%), also higher prevalence among community acquired (68.2%) as compared to hospital acquired strains (31.8%). All isolates with inducible resistance were 100% sensitive to vancomycin, linezolid and teicoplanin. To conclude, D-zone test should be performed routinely for appropriate prescription of clindamycin therapy for isolates with true clindamycin sensitivity only.


Keywords: Coagulase-negative Staphylococci, D-zone test, Inducible clindamycin resistance, Antibiotic susceptibility, MRCoNS; MSCoNS
Download this article as Download

How to cite this article:

Razia Khatoon and Noor Jahan. 2018. Evaluation of Prevalence of Inducible Clindamycin Resistance among Coagulase Negative Staphylococci (CoNS) Isolated from Various Clinical Samples in a Tertiary Care Hospital of North India.Int.J.Curr.Microbiol.App.Sci. 7(2): 513-522. doi: https://doi.org/10.20546/ijcmas.2018.702.065