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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 3625-3635
DOI: https://doi.org/10.20546/ijcmas.2018.701.426


Toxicity Assessment of an Aqueous Extract of the Stem Bark of Spondias mombin (Anacardiaceae) in wistar albino rats
Gbogbo Moussa1, 2*, Toure Alassane3, Kouadio YaoEmile2, Oussou N'guessan Jean-Baptiste2, Kone Mama2, Diby Yao Bernard2 and Yapo AngouePaul2
1Department of Biochemistry-Microbiology, Jean Lorougnon-Guede University; BP 150 Daloa
2Laboratory of Physiology, Pharmacology and Pharmacopoeia, Nangui Abrogoua University, 01 BP 801 Abidjan 01
3CIRDES, Bobo-Dioulasso, 01 BP 454 Bobo-Dioulasso 01
*Corresponding author
Abstract:

The total aqueous extract of the stem bark of Spondias mombin L. (Anacardiaceae) is involved in the treatment of several pathologies including digestive disorders in Cote d'Ivoire. To verify its safety, three doses (250, 500 and 1000 mg/kg body weight) of Spondias mombin extractis administered daily orally to three groups of albino Wistar rats for 28 days. The control group received distilled water. Blood sample is taken to evaluate the rate of erythrocytes, hemoglobin and hematocrit of all experimental rats. A blood smear and hemolysis tests were performed to determine the effect of the extract on the quality of erythrocytes. After 28 days, a histological study was also performed on the liver and kidneys of all rats. The results of this work indicated a significant decrease in erythrocyte parameters studied. On blood smears, hypochromia, target red blood cells, and schizocytes were observed in the rats treated with 500 and 1000 mg/kg b.w. In vitro study on rat red blood cells indicated a progressive increase in hemolysis percentages over time in tubes with different concentrations of extract. Histological study of the liver of the kidneys revealed steatosis, cell death by apoptosis, necrosis and calcification of nephron tubules.


Keywords: Spondias mombin, aqueous extract, blood smear, hemolysis, histological sections, rat
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How to cite this article:

Gbogbo Moussa, Toure Alassane, Kouadio YaoEmile, Oussou N'guessan Jean-Baptiste, Kone Mama, Diby Yao Bernard and Yapo AngouePaul. 2018. Toxicity Assessment of an Aqueous Extract of the Stem Bark of Spondias mombin (Anacardiaceae) in wistar albino rats.Int.J.Curr.Microbiol.App.Sci. 7(1): 3625-3635. doi: https://doi.org/10.20546/ijcmas.2018.701.426