National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
The total aqueous extract of the stem bark of Spondias mombin L. (Anacardiaceae) is involved in the treatment of several pathologies including digestive disorders in Cote d'Ivoire. To verify its safety, three doses (250, 500 and 1000 mg/kg body weight) of Spondias mombin extractis administered daily orally to three groups of albino Wistar rats for 28 days. The control group received distilled water. Blood sample is taken to evaluate the rate of erythrocytes, hemoglobin and hematocrit of all experimental rats. A blood smear and hemolysis tests were performed to determine the effect of the extract on the quality of erythrocytes. After 28 days, a histological study was also performed on the liver and kidneys of all rats. The results of this work indicated a significant decrease in erythrocyte parameters studied. On blood smears, hypochromia, target red blood cells, and schizocytes were observed in the rats treated with 500 and 1000 mg/kg b.w. In vitro study on rat red blood cells indicated a progressive increase in hemolysis percentages over time in tubes with different concentrations of extract. Histological study of the liver of the kidneys revealed steatosis, cell death by apoptosis, necrosis and calcification of nephron tubules.
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