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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 3617-3624
DOI: https://doi.org/10.20546/ijcmas.2018.701.425


Antiviral prospective of Tinospora cordifolia on HSV-1
R. Pruthvish and S.M.Gopinatha*
Department of Biotechnology, Acharya Institute of Technology, Bengaluru, em>Karnataka 560107, India
*Corresponding author
Abstract:

HSV-1 also known as Oral herpes causes sores or lesions in the gums or near the mouth. Dry stem of Tinospora cordifolia is powdered and extraction is carried out in soxhlet apparatus using the solvent Methanol and Ethyl Acetate in the ratio 80:20. The crude extract was subjected to prelimnary phytochemical analysis which indicated the presence of Saponins, alkaloids, phytosterols and triterpenoids. The preparation of virus pool was carried out using Vero cell lines. MTT assay was conducted and the cytotoxicity level of T.corfiolia on the cells was obtained as 315.68±7.8. Viral titration was carried out followed by Virucidal assay and it was concluded that T.cordifolia inhibits the growth of HSV by 61.43% at 10TCID50.


Keywords: Herpes simplex Virus; Tinospora Cordifolia; Virus titration; Virucidal assay
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How to cite this article:

Pruthvish, R., and Gopinatha, S.M. 2018. Antiviral prospective of Tinospora cordifolia on HSV-1.Int.J.Curr.Microbiol.App.Sci. 7(1): 3617-3624. doi: https://doi.org/10.20546/ijcmas.2018.701.425