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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(7): 54-60
DOI: http://dx.doi.org/10.20546/ijcmas.2016.507.004


Speciation of Candida Isolated from Various Clinical Samples and their Antifungal Susceptibility Profile in a Tertiary Care Hospital
M.V. Natasha1*, Y. Raksha2 and B.V. Navaneeth3
1Department of Microbiology, Gulbarga Institute Of Medical Sciences
Veeresh Nagar, Gulbarga.585105, India
2Department of Microbiology, ESIC-MC-PGIMSR, Rajajinagar,Bengaluru-560010, India
3Department of Microbiology, ESIC-MC-PGIMSR, Rajajinagar,Bengaluru-560010, India
*Corresponding author
Abstract:

Candida spp. can cause a wide variety of infections in immunosuppressed patients of long term broad – spectrum antibiotics, steroids or other immunosuppressive agents, diabetes mellitus, AIDS, Malignancy, Neutropenia. Although the majority of infections are caused by Candida albicans, Non-C. albicans Candida (NCAC) species are emerging as important pathogen in humans. Our study included 130 clinical isolates which showed gram positive budding yeasts cells with or without pseudohyphae. KOH mount, germ tube, Carbohydrate assimilation test and fermentation test and antifungal susceptibility by disc diffusion method was done. Most of the Candida isolates were from sputum (45%)samples followed by urine (24%), endotracheal tip(14%), vaginal swabs(9%),blood (4%)and pus(4%).Female (57.6%) more prone to Candida infections than male(42.3%).54 % of the patients from whom candida was isolated had been treated with >2 antibiotics, 15%treated with >3 antibiotics, 17%Diabetis Mellitus, 16% Neutropenia, 8 % Tuberculosis and Treatment with Steroids,6% Malignancy,2% HIV. Most common Candida species isolated belonged to Candida albicans (29.2%).C parapsilosis (15.3%),C tropicalis (12.3%), C glabrata (11.5%),C krusei (9.2%), C lusitanae (9.2%), C guillermondi (8.46%), C dubliniensis (4.6%).65% of the total isolates were sensitive to Fluconazole and 82%of the total isolates were sensitive to Voriconazole.


Keywords: Candida albicans, Non-C. albicans Candida (NCAC),Antifungal Susceptibility Profile.
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How to cite this article:

Natasha, M.V., Y. Raksha and Navaneeth, B.V. 2016. Speciation of Candida Isolated from Various Clinical Samples and their Antifungal Susceptibility Profile in a Tertiary Care Hospital.Int.J.Curr.Microbiol.App.Sci. 5(7): 54-60. doi: http://dx.doi.org/10.20546/ijcmas.2016.507.004