National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Streptococcus mutans is a primary dental pathogen causes dental caries, its multidrug resistance increases the complications in treating the diseases. Many bacteria in a microbially rich environment like mangrove ecosystem tend to produce a variety of antimicrobial compounds. In the present study, a bacterium was isolated which showed excellent anti-streptococcal activity against human oral pathogen Streptococcus mutans. Antibacterial activity not recorded for any other pathogens used. The active bacterium identified as Bacillus subtilis using phenotypic characterization. Further, the active compound from the culture supernatant of B. subtilis was partially purified by precipitation and solvent extraction. The active compound proved to be a peptide in nature. The minimal inhibitory concentration (MIC) of the partially purified anti-streptococcal peptide was 123±10 µg ml-1, which is comparable to commercial antibiotics. The anti-streptococcal peptide found in the study can be evaluated for its use in treating dental diseases.
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