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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 1374-1378
DOI: https://doi.org/10.20546/ijcmas.2018.701.167


Novel Anti-Streptococcal Peptide Produced by Mangrove Bacteria Bacillus subtilis
Joseph Sahayarayan Jesudass1*, Karthikeyan Kandasamy3,Sathyamoorthi Thangavelu2 and Arivoli Appavu4
1Department of Bioinformatics
2Department of Microbiology, Alagappa University, Karaikudi 630003, India
3Department of Food Science and Nutrition, Periyar University, Salem 636011, India
4Department of Environmental Sciences, Government Arts College, Ariyalur 621713, India
*Corresponding author
Abstract:

Streptococcus mutans is a primary dental pathogen causes dental caries, its multidrug resistance increases the complications in treating the diseases. Many bacteria in a microbially rich environment like mangrove ecosystem tend to produce a variety of antimicrobial compounds. In the present study, a bacterium was isolated which showed excellent anti-streptococcal activity against human oral pathogen Streptococcus mutans. Antibacterial activity not recorded for any other pathogens used. The active bacterium identified as Bacillus subtilis using phenotypic characterization. Further, the active compound from the culture supernatant of B. subtilis was partially purified by precipitation and solvent extraction. The active compound proved to be a peptide in nature. The minimal inhibitory concentration (MIC) of the partially purified anti-streptococcal peptide was 123±10 µg ml-1, which is comparable to commercial antibiotics. The anti-streptococcal peptide found in the study can be evaluated for its use in treating dental diseases.


Keywords: Bacillus subtilis, Streptococcus mutans, Antimicrobial, Muthupet mangrove, Anti-streptococcal peptide
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How to cite this article:

Joseph Sahayarayan Jesudass, Karthikeyan Kandasamy, Sathyamoorthi Thangavelu and Arivoli Appavu. 2018. Novel Anti-Streptococcal Peptide Produced by Mangrove Bacteria Bacillus subtilis.Int.J.Curr.Microbiol.App.Sci. 7(1): 1374-1378. doi: https://doi.org/10.20546/ijcmas.2018.701.167