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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 1000-1006
DOI: https://doi.org/10.20546/ijcmas.2018.701.120


Phytochemical Analysis and Hepatoprotective Effect of Hydroethanolic Extract of Stem Bark of Oroxylum indicum
Sushree Sangita Mohapatra1*, R.K. Roy1, P. Mohan1, T.N. Upadhyaya2 and J. Sarma1
1Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Khanapara, Guwahati-781022, Assam, India
2Department of Veterinary Pathology, College of Veterinary Science, Khanapara, Guwahati-781022, Assam, India
*Corresponding author
Abstract:

The present study was conducted to evaluate the hepatoprotective effect of the Hydroethanolic extract of the stem bark Oroxylum indicum against CCl4 induced hepatotoxicity. The hydroethanolic extract was prepared. Albino Wistar rats were taken for the study. The extract was prepared at a dose rate of 100mg/kg body weight, 300mg/kg body weight, 900mg/kg body weight. Carbon tetrachloride was used to induce hepatotoxicity. The extract was screened for phytochemical constituents. Enzyme activity of Alanine aminotransamenase, Alkaline phosphatase, Gamma-glutamyltransferase was tested and level of serum total bilirubin and total protein were analyzed. Results found that the shade-dried hydroethanolic bark extract has saponin, tannin, flavonoids, steroids, and glycosides. Biochemical analysis and Histopathological findings revealed the significant (p≤0.001) decrease of liver biomarkers in a dose-dependent manner resulting in the hepatoprotective effect of Oroxylum indicum over the carbon tetrachloride-induced hepatotoxicity and the results of the group treated with 900mg/kg body weight were comparable to as of control group. Hydroethanolic extract of O. indicum found to have hepatoprotective effect against CCl4 induced hepatotoxicity in Wistar rats.


Keywords: Hepatoprotective effect, Oroxylum indicum, Silymarin, Hydroethanolic extract
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How to cite this article:

Sushree Sangita Mohapatra, R.K. Roy, P. Mohan, T.N. Upadhyaya and Sarma, J. 2018. Phytochemical Analysis and Hepatoprotective Effect of Hydroethanolic Extract of Stem Bark of Oroxylum indicum.Int.J.Curr.Microbiol.App.Sci. 7(1): 1000-1006. doi: https://doi.org/10.20546/ijcmas.2018.701.120