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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 594-601
DOI: https://doi.org/10.20546/ijcmas.2018.701.072


The Incidence of Carbapenem Resistance in Klebsiella pneumoniae Subspecies pneumoniae (CRKP) and Antibiotic Susceptibility Profile of Klebsiella pneumoniae Subspecies pneumoniae strains
Priyanka Singh*
Department of Microbiology, RKDF Medical College and Research Center, Jatkhedi Hosangabad Road, Bhopal-462026, India
*Corresponding author
Abstract:

Carbapenamases producing Klebsiella pneumoniae subspp pneumoniae strains are increasing worldwide and pose a major threat to patient care. Hence, the present study was undertaken to detect the incidence of Carbapenamases producing Klebsiella pneumoniae subspp pneumoniae strains isolated from different clinical specimens in the department of Microbiology and Antibiotic Susceptibility profile of Klebsiella pneumoniae subspecies pneumoniae strains. The study was approved by Institutional Ethical Committee (IEC). The type of study was cross sectional observational study. 300 Klebsiella pneumoniae subspp pneumoniae strains were studied. Antibiotic susceptibility test was done by Kirby-Bauer disc diffusion method. In our present study, 29.3% strains were CRKP. Out of total 300 Klebsiella pneumoniae subspp pneumoniae strains, 83 (27.7%), 90 (30%), 56 (18.7%), 40 (13.3%) and 96 (32%) were positive by Classical Hodge test, Modified Hodge test, MBL confirmatory test, KPC confirmatory test and Carbapenem hydrolysis positive due to MBL and KPC production respectively. In the present study (19/300 i.e.6.3%) Klebsiella pneumonia strains were MBL and KPC Co- producers. 13.3% KPC, 18.7% Klebsiella pneumoniae strains were MBL producing Klebsiella pneumoniae strains were isolated. All 300 Klebsiella pneumoniae strains studied were sensitive to colistin (100%), followed by Imipenem (70.6%). All Klebsiella pneumoniae subspp pneumoniae strains, isolated in Clinical Microbiology Laboratory should be tested phenotypically for Carbapenamases production.


Keywords: Klebsiella pneumoniae, CRKP
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How to cite this article:

Priyanka Singh. 2018. The Incidence of Carbapenem Resistance in Klebsiella pneumoniae Subspecies pneumoniae (CRKP) and Antibiotic Susceptibility Profile of Klebsiella pneumoniae Subspecies pneumoniae strains.Int.J.Curr.Microbiol.App.Sci. 7(1): 594-601. doi: https://doi.org/10.20546/ijcmas.2018.701.072