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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 431-438
DOI: https://doi.org/10.20546/ijcmas.2018.701.050


In silico Identification of Inhibitors from Salacia reticulate Plant against Diabetic Target Protein
D. Ramakrishna, A.T. Shashank, S. Kiran, K.M. Kumar and G.A. Ravishankar*
Dr. C.D Sagar Centre for Life Sciences, Biotechnology Department, Dayananda Sagar College of Engineering, Dayananda Sagar Institutions, Kumaraswamy Layout, Bengaluru 560 078, Karnataka, India
*Corresponding author
Abstract:

Salacia species for its antdiabetic property especially of root, stem and leaf extract. Plant produces several phytochemicals responsible for antidiabetic activity. Four proteins were selected based on literature survey and retrieved from protein data bank. The 18 chemicals were converted into 3 D structure and docked with diabetic protein. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)- is a chemical expressed in salacia which showed good antidiabetic property among 18 other chemicals. Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)- inhibit the diabetic causing proteins and regulate the glucose level in animal system. This study will helpful in future for developing a novel drug to treat diabetes by using advance in silico tools


Keywords: In silico, Diabetic, Phytochemicals and Benzeneacetonitrile, .Alpha.-(.Beta.-D-Glucopyranosyloxy)-, (R)
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How to cite this article:

Ramakrishna, D., A.T. Shashank, S. Kiran, K.M. Kumar and Ravishankar, G.A. 2018. In silico Identification of Inhibitors from Salacia reticulata Plant against Diabetic Target Protein.Int.J.Curr.Microbiol.App.Sci. 7(1): 431-438. doi: https://doi.org/10.20546/ijcmas.2018.701.050