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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2019: 96.39
Index Copernicus ICI Journals Master List 2019 - IJCMAS--ICV 2019: 96.39
For more details click here

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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 206-213
DOI: https://doi.org/10.20546/ijcmas.2018.701.023


Histopathological Changes and Tissue Residue Deposition in Broiler Birds Following Profenofos Administration 
Kafle1*, D.C. Roy1, J. Sarma1, T.N. Upadhyaya2, J.D. Mahanta3 and R. Gogoi4
1Department of Pharmacology and Toxicology, 2Department of Veterinary Pathology, 3Department of Poultry Science, 4Department of Pharmacology and Toxicology, College of Veterinary Science, A.A.U., Khanapara, Guwahati-781022, Assam, India
*Corresponding author
Abstract:

To study the Histopathological changes and tissue residue deposition in broiler birds following profenofos administration. Twenty birds were divided into two groups, 10 in each group. Group I served as control and group II was treated with single oral dose of Profenofos (16 mg/kg). Representative pieces of tissues from liver, kidney, lung, brain and muscle were collected for histopathological examination and residue estimation. Birds treated with profenofos showed marked histopathological changes. Cellular swelling, coagulative necrosis, hydropic degeneration and congestion were observed in most of the tissue examined. The brain section revealed neuronophagia and setellosis. The concentration of profenofos residues ranged from 0.02 to 0.05 ug/g in tested tissues. The level of residue in tissue was found to be maximum in brain while least was observed in muscle. Profenofos administration at the dose of 16 mg/kg cause considerable histopathological changes and little tissue residue deposition.


Keywords: Profenofos, Acute, Histopathology, Broiler
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How to cite this article:

Kafle, A., D.C. Roy, J. Sarma, T.N. Upadhyaya, J.D. Mahanta and Gogoi, R. 2018. Histopathological Changes and Tissue Residue Deposition in Broiler Birds Following Profenofos Administration.Int.J.Curr.Microbiol.App.Sci. 7(1): 206-213. doi: https://doi.org/10.20546/ijcmas.2018.701.023