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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2018.7(1): 158-167
DOI: https://doi.org/10.20546/ijcmas.2018.701.017


Qualitative and Quantitative Estimation of Crown Gall Inhibitory Activity of Curcumin, Hydroalcoholic Extract of Curcuma aromatica Salisb and Curcuma zedoaria (Christm.) Roscoe
Srividya Ammayappan Rajam1*, Vishnu Varthan Vaithiyalingam Jagannathan2, Boguda Anantharamaiah Vishwanath1 and Kolidhasan Ramkumar1
1Aditya Bangalore Institute for Pharmacy Education and Research, Bangalore-560068, Karnataka, India
2Department of Pharmacy, SRM University, Kattangulathur, Kanchipuram-603203, Tamilnadu, India
*Corresponding author
Abstract:

Crown gall is a neoplastic disease characterized by the transformation of normal plant cells into autonomous tumor cells in a short period of time in more than 60 families of dicots and many gymnosperms. This paper deals with the comparison of crown gall inhibitory activity of Curcumin, a hydroalcoholic extract of Curcuma aromatica and Curcuma zedoaria both qualitative and quantitative. Qualitative assay results showed that the hydroalcoholic extract of Curcuma aromatica, Curcuma zedoaria, and Curcumin found to possess crown gall inhibitory activity which was found to increase the concentration of the drug. Among the three tested compound curcumin showed good crown gall inhibitory activity from the concentration 500 μg/ml to 1000 μg/ml. In the quantitative assay, all the three tested compounds showed a good percentage of inhibition which was found to be dose-dependent. Among the three compound curcumin showed 56.13% of tumor inhibition at the concentration of 1000 μg/ml, whereas the hydroalcoholic extract of Curcuma aromatica and Curcuma zedoaria showed 29.59 % and 23.46% inhibition of tumor. The less crown gall inhibitory activity of a hydroalcoholic extract of Curcuma aromatica and Curcuma zedoaria might be due to the lower concentration of curcumin.


Keywords: Crown gall inhibition, Curcumin, Curcuma aromatica, Curcuma zedoaria, Qualitative assay, Quantitative assay
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How to cite this article:

Srividya Ammayappan Rajam, Vishnu Varthan Vaithiyalingam Jagannathan, Boguda Anantharamaiah Vishwanath and Kolidhasan Ramkumar. 2018. Qualitative and Quantitative Estimation of Crown Gall Inhibitory Activity of Curcumin, Hydroalcoholic Extract of Curcuma aromatica Salisb and Curcuma zedoaria (Christm.) Roscoe.Int.J.Curr.Microbiol.App.Sci. 7(1): 158-167. doi: https://doi.org/10.20546/ijcmas.2018.701.017