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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39 For more details click here
National Academy of Agricultural Sciences (NAAS) : NAAS Score: *5.38 (2020) [Effective from January 1, 2020]For more details click here

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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2020)
[Effective from January 1, 2020]
For more details click here

ICV 2018: 95.39
Index Copernicus ICI Journals Master List 2018 - IJCMAS--ICV 2018: 95.39
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
NAAS RATING 2020: 5.38

Int.J.Curr.Microbiol.App.Sci.2016.5(1): 576-585
DOI: http://dx.doi.org/10.20546/ijcmas.2016.501.059


Antibiotic Associated Diarrhea and Incidence of Clostridium difficile Infection and Colonization in Infants and Children in Tanta University Hospital, Egypt
Marwa Ahmed Ali Abd El-Wahab, Ahmed Mohamed Naeem, Abd EL- Rahman Mohamed EL-Mashad and Nehad Refhat Mostafa Sallam
Department of Microbiology and Immunology, Faculty of Medicine, Tanta, Egypt
Department of Pediatrics, Faculty of Medicine, Tanta, Egypt
*Corresponding author
Abstract:

Injudicious use of antibiotics in hospitalized patients increases the risk of Clostridium dif icile associated diarrhea (CDAD). This study was conducted to determine the incidence of C. difficile as a cause of antibiotic associated diarrhea in pediatric patients in our hospital. Sixty infants and children with a history of antibiotic intake whether having diarrhea or not and 30 age and sex matched patients with no history of antibiotic intake were studied prospectively over a period of one year. Stool samples were processed for C. difficile isolation and examined for C. dif icile toxin A and B by the enzyme-linked immunosorbent assay. 26 out of 60 cases (43.3%) suffered from diarrhea. Only (22/60) showed positive stool culture for C. dif icile, 18 out of them had diarrhea while the remaining 4 patients had no diarrhea and only colonized with toxigenic C. dif icile representing 11.8% of total 34 cases without diarrhea. Toxin A and B were detected in 16 patients including 4 asymptomatic carriers and 12 out of 26 cases with diarrhea representing 46.2%. The incidence of CDAD in our hospital was 46.2%. The asymptomatic carriage rate was 11.8%.


Keywords: CDAD, C. difficile toxins, C. difficile colonization, Stool culture, Egypt
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How to cite this article:

Int.J.Curr.Microbiol.App.Sci. 5(1): 576-585. doi: http://dx.doi.org/10.20546/ijcmas.2016.501.059