National Academy of Agricultural Sciences (NAAS)
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PRINT ISSN : 2319-7692
Online ISSN : 2319-7706 Issues : 12 per year Publisher : Excellent Publishers Email : editorijcmas@gmail.com / submit@ijcmas.com Editor-in-chief: Dr.M.Prakash Index Copernicus ICV 2018: 95.39 NAAS RATING 2020: 5.38 |
Bacteria have different mechanisms by which they become resistant to antimicrobials like reduced uptake, efflux pumps, drug inactivating enzymes like β-lactamases etc. New Delhi Metallo-β-lactamase-1 (NDM-1) is an enzyme which can break down and destroy multiple classes of antibiotics. Infections with multidrug resistant organisms like those carrying blaNDM-1 gene can lead to adverse outcomes esp. in critically ill patients, patients undergoing organ transplant and other major surgeries. The treatment options are quite limited with the main options available for sometime being limited to colistin and tigecycline which have side effects like renal toxicity. Antimicrobial susceptibility testing using VITEK-2 (biomerieux®) ofNDM-1 producing bacteria from the ICU admitted patients showed that nitrofurantoin, gentamicin, tobramycin, levofloxacin and trimethoprim/sulfamethoxazole combination were effective against some strains carrying the gene.
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