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International Journal of Current Microbiology and Applied Sciences (IJCMAS)
IJCMAS is now DOI (CrossRef) registered Research Journal. The DOIs are assigned to all published IJCMAS Articles.
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National Academy of Agricultural Sciences (NAAS)
NAAS Score: *5.38 (2019)
[Effective from January 1, 2019]
For more details click here

ICV 2017: 100.00
Index Copernicus ICI Journals Master List 2017 - IJCMAS--ICV 2017: 100.00
For more details click here

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Original Research Articles

PRINT ISSN : 2319-7692
Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : editorijcmas@gmail.com / submit@ijcmas.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2017: 100.00
NAAS RATING 2018: 5.38

Int.J.Curr.Microbiol.App.Sci.2017.6(12): 2803-2806
DOI: https://doi.org/10.20546/ijcmas.2017.612.325


Probable Treatment Options against Infections with Bacteria Carrying blaNDM-1 Gene
Anuj Sud1*, Beena Uppal2, Swati Sharma3, Prabhav Aggarwal4 and Rakesh Kumar5
1Department of Microbiology, Lok Nayak Hospital and Maulana Azad Medical College,New Delhi-110002, India
2Department of Microbiology, Dr Baba Saheb Ambedkar Medical College, Sector-6,Rohini, New Delhi-110085, India
3Department of Microbiology, Rajiv Gandhi Superspeciality Hospital, Tahirpur, Delhi, India
4Department of Microbiology, ESI Dental College, Sector-15, Rohini, New Delhi-110089, India
5Department of Anaesthesiology and Critical Care, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi-110002, India
*Corresponding author
Abstract:

Bacteria have different mechanisms by which they become resistant to antimicrobials like reduced uptake, efflux pumps, drug inactivating enzymes like β-lactamases etc. New Delhi Metallo-β-lactamase-1 (NDM-1) is an enzyme which can break down and destroy multiple classes of antibiotics. Infections with multidrug resistant organisms like those carrying blaNDM-1 gene can lead to adverse outcomes esp. in critically ill patients, patients undergoing organ transplant and other major surgeries. The treatment options are quite limited with the main options available for sometime being limited to colistin and tigecycline which have side effects like renal toxicity. Antimicrobial susceptibility testing using VITEK-2 (biomerieux®) ofNDM-1 producing bacteria from the ICU admitted patients showed that nitrofurantoin, gentamicin, tobramycin, levofloxacin and trimethoprim/sulfamethoxazole combination were effective against some strains carrying the gene.


Keywords: blaNDM-1 gene, NDM-1 producing bacteria, NDM-1 treatment, Multidrug resistance, Hospital acquired infection.
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How to cite this article:

Anuj Sud, Beena Uppal, Swati Sharma, Prabhav Aggarwal and Rakesh Kumar. 2017. Probable Treatment Options against Infections with Bacteria Carrying blaNDM-1 Gene.Int.J.Curr.Microbiol.App.Sci. 6(12): 2803-2806. doi: https://doi.org/10.20546/ijcmas.2017.612.325